دورية أكاديمية
Gastrointestinal Hormones in Healthy Adults: Reliability of Repeated Assessments and Interrelations with Eating Habits and Physical Activity
العنوان: | Gastrointestinal Hormones in Healthy Adults: Reliability of Repeated Assessments and Interrelations with Eating Habits and Physical Activity |
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المؤلفون: | Wortha, Silke M., Wüsten, Katharina A., Witte, Veronica A., Bössel, Nicole, Keßler, Wolfram, Vogelgesang, Antje, Flöel, Agnes |
المصدر: | Nutrients 13(11), 3809 (2021). doi:10.3390/nu13113809 special issue: "Gastrointestinal Luminal Nutrient Sensing and Physiological Responses—from Basic to Disease" |
بيانات النشر: | MDPI |
سنة النشر: | 2021 |
مصطلحات موضوعية: | info:eu-repo/classification/ddc/610, Adult, Anthropometry, Biomarkers: blood, Blood Glucose: analysis, Clinical Trials as Topic, Exercise: physiology, Feeding Behavior: physiology, Female, Gastrointestinal Hormones: blood, Ghrelin: blood, Glucagon-Like Peptide 1: blood, Glycated Hemoglobin: analysis, Healthy Volunteers, Humans, Ideal Body Weight, Leptin: blood, Longitudinal Studies, Male, Nutrition Assessment, Pancreatic Polypeptide: blood, Pilot Projects, Reproducibility of Results |
جغرافية الموضوع: | DE |
الوصف: | Background: Gastrointestinal hormones (GIHs) are crucial for the regulation of a variety of physiological functions and have been linked to hunger, satiety, and appetite control. Thus, they might constitute meaningful biomarkers in longitudinal and interventional studies on eating behavior and body weight control. However, little is known about the physiological levels of GIHs, their intra-individual stability over time, and their interaction with other metabolic and lifestyle-related parameters. Therefore, the aim of this pilot study is to investigate the intra-individual stability of GIHs in normal-weight adults over time. Methods: Plasma concentrations of ghrelin, leptin, GLP-1 (glucagon-like-peptide), and PP (pancreatic polypeptide) were assessed by enzyme-linked immunosorbent assay (ELISA) in 17 normal-weight, healthy adults in a longitudinal design at baseline and at follow-up six months later. The reliability of the measurements was estimated using intra-class correlation (ICC). In a second step, we considered the stability of GIH levels after controlling for changes in blood glucose and hemoglobin A1 (HbA1c) as well as self-reported physical activity and dietary habits. Results: We found excellent reliability for ghrelin, good reliability for GLP1 and PP, and moderate reliability for leptin. After considering glucose, HbA1c, physical activity, and dietary habits as co-variates, the reliability of ghrelin, GLP1, and PP did not change significantly; the reliability of leptin changed to poor reliability. Conclusions: The GIHs ghrelin, GLP1, and PP demonstrated good to excellent test–retest reliability in healthy individuals, a finding that was not modified after adjusting for glucose control, physical activity, or dietary habits. Leptin showed only moderate to poor reliability, which might be linked to weight fluctuations, albeit small, between baseline and follow-up assessment in our study sample. Together, these findings support that ghrelin, GLP1, and PP might be further examined as biomarkers in studies ... |
نوع الوثيقة: | article in journal/newspaper |
اللغة: | English |
العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/pmid:34836065; info:eu-repo/semantics/altIdentifier/issn/2072-6643; https://pub.dzne.de/record/162735Test; https://pub.dzne.de/search?p=id:%22DZNE-2021-01392%22Test |
الإتاحة: | https://doi.org/10.3390/nu13113809Test https://pub.dzne.de/record/162735Test https://pub.dzne.de/search?p=id:%22DZNE-2021-01392%22Test |
حقوق: | info:eu-repo/semantics/openAccess |
رقم الانضمام: | edsbas.71818590 |
قاعدة البيانات: | BASE |
الوصف غير متاح. |