دورية أكاديمية
Correlation between C-reactive protein and the inflammatory ratios in acute schizophrenia inpatients: are they associated?
| العنوان: | Correlation between C-reactive protein and the inflammatory ratios in acute schizophrenia inpatients: are they associated? |
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| المؤلفون: | Llorca‑Bofí, Vicent, Bioque, Miquel, Font, Maria, Gich, Ignasi, Mur, Maria |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2023 |
| المجموعة: | Universitat de Lleida: Repositori Obert UdL |
| مصطلحات موضوعية: | Schizophrenia, C-Reactive Protein, Inflammatory ratios, Neutrophil-Lymphocyte Ratio, Monocyte-Lymphocyte Ratio, Platelet-Lymphocyte Ratio |
| الوصف: | C-reactive protein (CRP) and inflammatory ratios have been proposed to study immune dysregulation in schizophrenia. Nevertheless, links between CRP and inflammatory ratios in acute SCZ inpatients have been understudied. This study investigated the relationship between CRP and inflammatory ratios (Neutrophil-Lymphocyte Ratio [NRL], Platelet-Lymphocyte Ratio [PLR], Monocyte-Lymphocyte ratio [MLR] and Basophil-Lymphocyte Ratio [BLR]) in a total of 698 acute SCZ inpatients; and analysed how this relationship is affected by sex and type of episode. CRP correlated with NLR (rs = 0.338, p < 0.001), PLR (rs = 0.271, p < 0.001) and MLR (rs = 0.148, p < 0.001) but not with BLR (rs = 0.059, p = 0.121). Multiple lineal regression analysis showed that high levels of NLR, MLR and PLR but not BLR were independently associated with high CRP levels. No sex-related variations were found. Significant associations were maintained for NLR and MLR in first-episode and multiepisode SCZ, although the strength of the association was stronger in multiepisode SCZ. Again, no sex-related differences were found in these associations. In conclusion, inflammatory ratios were low to moderately associated with CRP in acute SCZ inpatients. NLR and multiepisode SCZ showed the highest associations with CRP. Future studies should consider inflammatory ratios not as a substitute for CRP but as a complementary biomarker. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0022-3956 |
| العلاقة: | Reproducció del document publicat a https://doi.org/10.1016/j.jpsychires.2023.07.023Test; Journal of Psychiatric Research, 2023, vol. 165, p. 191-196; https://doi.org/10.1016/j.jpsychires.2023.07.023Test; https://repositori.udl.cat/handle/10459.1/464226Test |
| DOI: | 10.1016/j.jpsychires.2023.07.023 |
| الإتاحة: | https://doi.org/10.1016/j.jpsychires.2023.07.023Test https://repositori.udl.cat/handle/10459.1/464226Test |
| حقوق: | cc-by (c) Vicent Llorca-Bofí et al., 2023 ; Attribution 4.0 International ; info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.7145F6FE |
| قاعدة البيانات: | BASE |
| تدمد: | 00223956 |
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| DOI: | 10.1016/j.jpsychires.2023.07.023 |