دورية أكاديمية
Syndecan-1 and Free Indoxyl Sulfate Levels Are Associated with miR-126 in Chronic Kidney Disease
| العنوان: | Syndecan-1 and Free Indoxyl Sulfate Levels Are Associated with miR-126 in Chronic Kidney Disease |
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| المؤلفون: | Fourdinier, Ophélie, Glorieux, Griet, Brigant, Benjamin, Diouf, Momar, Pletinck, Anneleen, Vanholder, Raymond, Choukroun, Gabriel, Verbeke, Francis, Massy, Ziad, A, Metzinger-Le Meuth, Valérie, Metzinger, Laurent |
| المساهمون: | Université de Picardie Jules Verne (UPJV), CHU Amiens-Picardie, Ghent University Hospital, HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 (HEMATIM), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Hôpital Ambroise Paré AP-HP, Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, This research study was funded by SFNDT and Vifor (L.M., V.M.-L.M., B.B. and G.C.) |
| المصدر: | ISSN: 1661-6596. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2021 |
| المجموعة: | Université Paris 13: HAL |
| مصطلحات موضوعية: | uremic toxins, indoxyl sulfate, microRNA, miR-126, chronic kidney disease, biomarker, syndecan-1, endothelium dysfunction, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN] |
| الوصف: | International audience ; Chronic kidney disease (CKD) is a major cause of death worldwide and is associated with a high risk for cardiovascular and all-cause mortality. In CKD, endothelial dysfunction occurs and uremic toxins accumulate in the blood. miR-126 is a regulator of endothelial dysfunction and its blood level is decreased in CKD patients. In order to obtain a better understanding of the physiopathology of the disease, we correlated the levels of miR-126 with several markers of endothelial dysfunction, as well as the representative uremic toxins, in a large cohort of CKD patients at all stages of the disease. Using a univariate analysis, we found a correlation between eGFR and most markers of endothelial dysfunction markers evaluated in this study. An association of miR-126 with all the evaluated uremic toxins was also found, while uremic toxins were not associated with the internal control, specifically cel-miR-39. The correlation between the expression of endothelial dysfunction biomarker Syndecan-1, free indoxyl sulfate, and total p-cresyl glucuronide on one side, and miR-126 on the other side was confirmed using multivariate analysis. As CKD is associated with reduced endothelial glycocalyx (eGC), our results justify further evaluation of the role of correlated parameters in the pathophysiology of CKD. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-03374265; https://u-picardie.hal.science/hal-03374265Test; https://u-picardie.hal.science/hal-03374265/documentTest; https://u-picardie.hal.science/hal-03374265/file/Fourdinier%20et%20al%20IJMS%202021.pdfTest |
| DOI: | 10.3390/ijms221910549 |
| الإتاحة: | https://doi.org/10.3390/ijms221910549Test https://u-picardie.hal.science/hal-03374265Test https://u-picardie.hal.science/hal-03374265/documentTest https://u-picardie.hal.science/hal-03374265/file/Fourdinier%20et%20al%20IJMS%202021.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.7125131A |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms221910549 |
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