دورية أكاديمية
MitoQ prevents human breast cancer recurrence and lung metastasis in mice
| العنوان: | MitoQ prevents human breast cancer recurrence and lung metastasis in mice |
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| المؤلفون: | De Miranda Capeloa, Tania Isabel, Krzystyniak, Joanna, Canas Rodriguez, Amanda, Payen, Valery L, Zampieri, Luca, Pranzini, Erica, Derouane, Françoise, Vazeille, Thibaut, Bouzin, Caroline, Duhoux, Francois, Murphy, Michael P., Porporato, Paolo E, Sonveaux, Pierre |
| المساهمون: | UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - SSS/IREC/2IP - IREC Imaging Platform (2IP) |
| المصدر: | Cancers, Vol. 14, no. 6, p. 1488 [1-13] (2022) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2022 |
| المجموعة: | DIAL@USL-B (Université Saint-Louis, Bruxelles) |
| الوصف: | In oncology, the occurrence of distant metastases often marks the transition from curative to palliative care. Such outcome is highly predictable for breast cancer patients, even if tumors are detected early, and there is no specific treatment to prevent metastasis. Previous observations indicated that cancer cell mitochondria are bioenergetic sensors of the tumor microenvironment that produce superoxide to promote evasion. Here, we tested whether mitochondria-targeted antioxidant MitoQ is capable to prevent metastasis in the MDA-MB-231 model of triple-negative human breast cancer in mice and in the MMTV-PyMT model of spontaneously metastatic mouse breast cancer. At clinically relevant doses, we report that MitoQ not only prevented metastatic take and dissemination, but also local recurrence after surgery. We further provide in vitro evidence that MitoQ does not interfere with conventional chemotherapies used to treat breast cancer patients. Since MitoQ already successfully passed Phase I safety clinical trials, our preclinical data collectively provide a strong incentive to test this drug for the prevention of cancer dissemination and relapse in clinical trials with breast cancer patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2072-6694 |
| العلاقة: | boreal:259446; http://hdl.handle.net/2078.1/259446Test; info:pmid/; urn:EISSN:2072-6694 |
| DOI: | 10.3390/cancers14061488 |
| الإتاحة: | https://doi.org/10.3390/cancers14061488Test http://hdl.handle.net/2078.1/259446Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.70D26209 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20726694 |
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| DOI: | 10.3390/cancers14061488 |