دورية أكاديمية
Protecting effects of 4-octyl itaconate on neonatal hypoxic-ischemic encephalopathy via Nrf2 pathway in astrocytes ...
| العنوان: | Protecting effects of 4-octyl itaconate on neonatal hypoxic-ischemic encephalopathy via Nrf2 pathway in astrocytes ... |
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| المؤلفون: | Yang, Yanping, Li, Yang, Yang, Wenyi, Yang, Xueying, Luo, Man, Qin, Ling, Zhu, Junchao |
| بيانات النشر: | figshare |
| سنة النشر: | 2024 |
| المجموعة: | DataCite Metadata Store (German National Library of Science and Technology) |
| مصطلحات موضوعية: | Biochemistry, Cell Biology, Genetics, FOS Biological sciences, Molecular Biology, Neuroscience, Physiology, Chemical Sciences not elsewhere classified, Immunology, FOS Clinical medicine, Biological Sciences not elsewhere classified |
| الوصف: | Background Neonatal hypoxic-ischemic encephalopathy (HIE) is one of the most common neurological problems occurring in the perinatal period. However, there still is not a promising approach to reduce long-term neurodevelopmental outcomes of HIE. Recently, itaconate has been found to exhibit anti-oxidative and anti-inflammatory effects. However, the therapeutic efficacy of itaconate in HIE remains inconclusive. Therefore, this study attempts to explore the pathophysiological mechanisms of oxidative stress and inflammatory responses in HIE as well as the potential therapeutic role of a derivative of itaconate, 4-octyl itaconate (4OI). Methods We used 7-day-old mice to induce hypoxic-ischemic (HI) model by right common carotid artery ligation followed by 1 h of hypoxia. Behavioral experiments including the Y-maze and novel object recognition test were performed on HI mice at P60 to evaluate long-term neurodevelopmental outcomes. We employed an approach combining non-targeted metabolomics with ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://dx.doi.org/10.6084/m9.figshare.c.7240921Test |
| DOI: | 10.6084/m9.figshare.c.7240921.v1 |
| الإتاحة: | https://doi.org/10.6084/m9.figshare.c.7240921.v110.6084/m9.figshare.c.7240921Test https://springernature.figshare.com/collections/Protecting_effects_of_4-octyl_itaconate_on_neonatal_hypoxic-ischemic_encephalopathy_via_Nrf2_pathway_in_astrocytes/7240921/1Test |
| حقوق: | Creative Commons Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/legalcodeTest ; cc-by-4.0 |
| رقم الانضمام: | edsbas.709565E2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.6084/m9.figshare.c.7240921.v1 |
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