دورية أكاديمية
Interleukin-8 in Colorectal Cancer: A Systematic Review and Meta-Analysis of Its Potential Role as a Prognostic Biomarker
| العنوان: | Interleukin-8 in Colorectal Cancer: A Systematic Review and Meta-Analysis of Its Potential Role as a Prognostic Biomarker |
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| المؤلفون: | Bazzichetto C., Milella M., Zampiva I., Simionato F., Amoreo C. A., Buglioni S., Pacelli C., Le Pera L., Colombo T., Bria E., Zeuli M., Del Bufalo D., Sperduti I., Conciatori F. |
| المساهمون: | Bazzichetto, C., Milella, M., Zampiva, I., Simionato, F., Amoreo, C. A., Buglioni, S., Pacelli, C., Le Pera, L., Colombo, T., Bria, E., Zeuli, M., Del Bufalo, D., Sperduti, I., Conciatori, F. |
| بيانات النشر: | MDPI ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND |
| سنة النشر: | 2022 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | IL-8, advanced CRC, anti-angiogenic drug, chemotherapy, prognosi, tumor–stroma interactions |
| الوصف: | Among soluble actors that have emerged as druggable factors, the chemokine interleukin-8 (IL-8) has emerged as a possible determinant of response to immunotherapy and targeted treatment in several cancer types; however, its prognostic/predictive role in colorectal cancer (CRC) remains to be established. We: (i) conducted a systematic review of published literature on IL-8 expression in CRC; (ii) searched public transcriptomics databases; (iii) investigated IL-8 expression, by tumor and infiltrating cells, in a series of CRC samples; and (iv) carried out a meta-analysis of published literature correlating IL-8 expression and CRC prognosis. IL-8 possesses an important role as a mediator of the bidirectional crosstalk between tumor/stromal cells. Transcriptomic analysis indicated that specific IL-8 transcripts were significantly overexpressed in CRC compared to normal colon mucosa. Moreover, in our series we observed a statistically significant correlation between PTEN-loss and IL-8 expression by infiltrating mononuclear and tumor cells. In total, 12 papers met our meta-analysis inclusion criteria, demonstrating that high IL-8 levels significantly correlated with shorter overall survival and progression-free survival. Sensitivity analysis demonstrated a highly significant correlation with outcome for circulating, but not for tissue-detected, IL-8. IL-8 is overexpressed in CRC tissues and differentially produced by tumor or stromal components depending on CRC genetic background. Moreover, circulating IL-8 represents a strong prognostic factor in CRC, suggesting its use in the refining of prognostic CRC assessment and potentially the tailoring of therapeutic strategies in individual CRC patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/36289899; info:eu-repo/semantics/altIdentifier/wos/WOS:000872610900001; volume:10; issue:10; firstpage:2631; journal:BIOMEDICINES; https://hdl.handle.net/11573/1670563Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85140636787 |
| DOI: | 10.3390/biomedicines10102631 |
| الإتاحة: | https://doi.org/10.3390/biomedicines10102631Test https://hdl.handle.net/11573/1670563Test |
| رقم الانضمام: | edsbas.6F6DC8FA |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/biomedicines10102631 |
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