رسالة جامعية
Safety and efficacy of the Covid-19 Pfizer-BioNTech vaccination in pregnancy: A systematic review and meta-analysis
| العنوان: | Safety and efficacy of the Covid-19 Pfizer-BioNTech vaccination in pregnancy: A systematic review and meta-analysis |
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| المؤلفون: | Caroline Donaldson |
| سنة النشر: | 2024 |
| المجموعة: | The University of Auckland: Figshare |
| مصطلحات موضوعية: | Neonatology, Obstetrics and gynaecology, Nursing, Midwifery, Obsterics, Vaccination, Covid, Maternal outcomes, Neonatal outcomes |
| الوصف: | BACKGROUND: Pregnant women continue to be excluded from clinical trials, leading to vaccine hesitancy in this vulnerable population. Pfizer-BioNTech vaccination is the primary and widely available Coronavirus disease 2019 (Covid-19) vaccine in New Zealand (NZ). No systematic reviews and meta-analyses of the safety and efficacy outcomes of the maternal, foetal or neonate have been published. OBJECTIVE: To assess the safety and efficacy of the Covid-19 Pfizer-BioNTech, also referred to as BNT162b2, Comirnaty, or Tozinameran, vaccination during pregnancy. DESIGN: Systematic review and meta-analysis. METHOD: Electronic databases were searched (Embase, Medline, Web of Science, PubMed, Scopus) to the 4th of February 2023 for the safety and efficacy of the Pfizer-BioNTech vaccination during pregnancy. Studies included had to have a control or placebo group of unvaccinated pregnant women for comparison. Maternal safety outcomes were antepartum bleeding, postpartum haemorrhage, placental abruption, meconium-stained amniotic fluid, gestational diabetes, pregnancy-related hypertension, and death. Foetal and neonatal safety outcomes were miscarriages, stillborn, infant death, preterm delivery with subgroups of <32 weeks, <35 weeks, <37 weeks of gestation, heart malformation, congenital anomalies, neonatal intensive care unit (NICU) admission, neonatal seizures, neonatal respiratory complications, neonatal meconium aspiration syndrome, abnormal foetal heart rate, one and five minute Apgar scores ≤7, small for gestational age (SGA), and birth weight. Efficacy outcomes were documented Covid-19 infection, hospitalisation, severe or critical illness, intensive care unit (ICU) admission and death. Study titles and abstracts were screened, and the full text was obtained if it met the inclusion criteria. All included studies were assessed using the Cochrane Risk of Bias in non-randomized studies of exposure (ROBINS-E). The data was analysed using Revman odds ratios (OR) and 95% confidence intervals (95%CI) for binary ... |
| نوع الوثيقة: | thesis |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/thesis/Safety_and_efficacy_of_the_Covid-19_Pfizer-BioNTech_vaccination_in_pregnancy_A_systematic_review_and_meta-analysis/25754271Test |
| DOI: | 10.17608/k6.auckland.25754271.v1 |
| الإتاحة: | https://doi.org/10.17608/k6.auckland.25754271.v1Test https://figshare.com/articles/thesis/Safety_and_efficacy_of_the_Covid-19_Pfizer-BioNTech_vaccination_in_pregnancy_A_systematic_review_and_meta-analysis/25754271Test |
| حقوق: | CC BY 4.0 |
| رقم الانضمام: | edsbas.6F6023D |
| قاعدة البيانات: | BASE |
| DOI: | 10.17608/k6.auckland.25754271.v1 |
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