التفاصيل البيبلوغرافية
| العنوان: |
Comparative analysis of neural transcriptomes and functional implication of unannotated intronic expression |
| المؤلفون: |
Sun, Yazhou, Wang, Yaqiong, Hu, Yi, Chen, Gong, Ma, Hong |
| بيانات النشر: |
BioMed Central Ltd. |
| سنة النشر: |
2011 |
| المجموعة: |
BioMed Central |
| مصطلحات موضوعية: |
neural transcriptomes, stem cell, intronic expression, embryonic brain cortex, neonatal brain cortex |
| الوصف: |
Background The transcriptome and its regulation bridge the genome and the phenome. Recent RNA-seq studies unveiled complex transcriptomes with previously unknown transcripts and functions. To investigate the characteristics of neural transcriptomes and possible functions of previously unknown transcripts, we analyzed and compared nine recent RNA-seq datasets corresponding to tissues/organs ranging from stem cell, embryonic brain cortex to adult whole brain. Results We found that the neural and stem cell transcriptomes share global similarity in both gene and chromosomal expression, but are quite different from those of liver or muscle. We also found an unusually high level of unannotated expression in mouse embryonic brains. The intronic unannotated expression was found to be strongly associated with genes annotated for neurogenesis, axon guidance, negative regulation of transcription, and neural transmission. These functions are the hallmarks of the late embryonic stage cortex, and crucial for synaptogenesis and neural circuit formation. Conclusions Our results revealed unique global and local landscapes of neural transcriptomes. It also suggested potential functional roles for previously unknown transcripts actively expressed in the developing brain cortex. Our findings provide new insights into potentially novel genes, gene functions and regulatory mechanisms in early brain development. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
http://www.biomedcentral.com/1471-2164/12/494Test |
| الإتاحة: |
http://www.biomedcentral.com/1471-2164/12/494Test |
| حقوق: |
Copyright 2011 Sun et al; licensee BioMed Central Ltd. |
| رقم الانضمام: |
edsbas.6F51054B |
| قاعدة البيانات: |
BASE |
