دورية أكاديمية
Conversion from clinically isolated syndrome to multiple sclerosis. a large multicentre study.
| العنوان: | Conversion from clinically isolated syndrome to multiple sclerosis. a large multicentre study. |
|---|---|
| المؤلفون: | Jens Kuhle, Giulio Disanto, Ruth Dobson, Rocco Adiutori, Lucia Bianchi, Joanne Topping, Jonathan P. Bestwick, Ute Christiane Meier, Gloria Dalla Costa, Tessel Runia, Evgeniy Evdoshenko, Natalia Lazareva, Eric Thouvenot, Pietro Iaffaldano, Vita Direnzo, Mohsen Khademi, Fredrik Piehl, Manuel Comabella, Madeleine Sombekke, Joep Killestein, Harald Hegen, Stefan Rauch, Sandra D'Alfonso, Jose C. Alvarez Cermeño, Pavlína Kleinová, Dana Horáková, Romy Roesler, Florian Lauda, Sara Llufriu, Timucin Avsar, Ugur Uygunoglu, Ayse Altintas, Sabahattin Saip, Til Menge, Cecilia Rajda, Roberto Bergamaschi, Natalia Moll, Michael Khalil, Romain Marignier, Irena Dujmovic, Henrik Larsson, Clas Malmestrom, Elio Scarpini, Chiara Fenoglio, Stig Wergeland, Alice Laroni, ANNIBALI, Viviana, ROMANO, SILVIA, Alejandra D. Martínez, Adriana Carra, SALVETTI, Marco, Antonio Uccelli, Øivind Torkildsen, Kjell Morten Myhr, Daniela Galimberti, Konrad Rejdak, Jan Lycke, Jette L. Frederiksen, Jelena Drulovic, Christian Confavreux, David Brassat, Christian Enzinger, Siegrid Fuchs, Isabel Bosca, Jean Pelletier, Christophe Picard, Elena Colombo, Diego Franciotta, Tobias Derfuss, Raija LP Lindberg, Özgür Yaldizli, László Vécsei, Bernd C. Kieseier, Hans Peter Hartung, Pablo Villoslada, Aksel, Albert Saiz, Hayrettin Tumani, Eva Havrdová, Luisa M. Villar, Maurizio, Nadia Barizzone, Florian Deisenhammer, Charlotte Teunissen, Xavier Montalban, Mar Tintoré, Tomas Olsson, Maria Trojano, Sylvain Lehmann, Giovanni Castelnovo, Sergey Lapin, Rogier Hintzen, Ludwig Kappos, Roberto Furlan, Vittorio Martinelli, Giancarlo Comi, Sreeram V. Ramagopalan, Gavin Giovannoni |
| المساهمون: | Jens, Kuhle, Giulio, Disanto, Ruth, Dobson, Rocco, Adiutori, Lucia, Bianchi, Joanne, Topping, Jonathan P., Bestwick, Ute Christiane, Meier, Gloria Dalla, Costa, Tessel, Runia, Evgeniy, Evdoshenko, Natalia, Lazareva, Eric, Thouvenot, Pietro, Iaffaldano, Vita, Direnzo, Mohsen, Khademi, Fredrik, Piehl, Manuel, Comabella, Madeleine, Sombekke, Joep, Killestein, Harald, Hegen, Stefan, Rauch, Sandra, D'Alfonso, Jose C., Alvarez Cermeño, Pavlína, Kleinová, Dana, Horáková, Romy, Roesler, Florian, Lauda, Sara, Llufriu, Timucin, Avsar, Ugur, Uygunoglu, Ayse, Altinta, Sabahattin, Saip, Til, Menge, Cecilia, Rajda, Roberto, Bergamaschi, Natalia, Moll, Michael, Khalil, Romain, Marignier, Irena, Dujmovic, Henrik, Larsson, Clas, Malmestrom, Elio, Scarpini, Chiara, Fenoglio, Stig, Wergeland, Alice, Laroni, Annibali, Viviana, Romano, Silvia, Alejandra D., Martínez, Adriana, Carra, Salvetti, Marco, Antonio, Uccelli, Øivind, Torkildsen, Kjell Morten, Myhr, Daniela, Galimberti, Konrad, Rejdak, Jan, Lycke, Jette L., Frederiksen, Jelena, Drulovic, Christian, Confavreux, David, Brassat, Christian, Enzinger, Siegrid, Fuch, Isabel, Bosca, Jean, Pelletier, Christophe, Picard, Elena, Colombo, Diego, Franciotta, Tobias, Derfu, Raija LP, Lindberg, Özgür, Yaldizli, László, Vécsei, Bernd C., Kieseier, Hans Peter, Hartung, Pablo, Villoslada, Aksel, Albert, Saiz, Hayrettin, Tumani, Eva, Havrdová, Luisa M., Villar, Maurizio, Nadia, Barizzone, Florian, Deisenhammer, Charlotte, Teunissen, Xavier, Montalban, Mar, Tintoré, Tomas, Olsson, Maria, Trojano, Sylvain, Lehmann, Giovanni, Castelnovo, Sergey, Lapin, Rogier, Hintzen, Ludwig, Kappo, Roberto, Furlan, Vittorio, Martinelli, Giancarlo, Comi, Sreeram V., Ramagopalan, Gavin, Giovannoni |
| سنة النشر: | 2015 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | Clinically definite multiple sclerosis (CDMS), Epstein-Barr nuclear antigen 1 (EBNA-1), clinically isolated syndrome (CIS), oligoclonal bands (OCBs), serum 25-hydroxyvitamin D3 (25-OH-D) |
| الوصف: | Background and objective: We explored which clinical and biochemical variables predict conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (CDMS) in a large international cohort. Methods: Thirty-three centres provided serum samples from 1047 CIS cases with at least two years' follow-up. Age, sex, clinical presentation, T2-hyperintense lesions, cerebrospinal fluid (CSF) oligoclonal bands (OCBs), CSF IgG index, CSF cell count, serum 25-hydroxyvitamin D3 (25-OH-D), cotinine and IgG titres against Epstein-Barr nuclear antigen 1 (EBNA-1) and cytomegalovirus were tested for association with risk of CDMS. Results: At median follow-up of 4.31 years, 623 CIS cases converted to CDMS. Predictors of conversion in multivariable analyses were OCB (HR = 2.18, 95% CI = 1.71-2.77, p < 0.001), number of T2 lesions (two to nine lesions vs 0/1 lesions: HR = 1.97, 95% CI = 1.52-2.55, p < 0.001; >9 lesions vs 0/1 lesions: HR = 2.74, 95% CI = 2.04-3.68, p < 0.001) and age at CIS (HR per year inversely increase = 0.98, 95% CI = 0.98-0.99, p < 0.001). Lower 25-OH-D levels were associated with CDMS in univariable analysis, but this was attenuated in the multivariable model. OCB positivity was associated with higher EBNA-1 IgG titres. Conclusions: We validated MRI lesion load, OCB and age at CIS as the strongest independent predictors of conversion to CDMS in this multicentre setting. A role for vitamin D is suggested but requires further investigation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/25680984; info:eu-repo/semantics/altIdentifier/wos/WOS:000357738700009; volume:21; issue:8; firstpage:1013; lastpage:1024; numberofpages:12; journal:MULTIPLE SCLEROSIS; http://hdl.handle.net/11573/652121Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84929479105 |
| DOI: | 10.1177/1352458514568827 |
| الإتاحة: | https://doi.org/10.1177/1352458514568827Test http://hdl.handle.net/11573/652121Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.6F49B8CA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/1352458514568827 |
|---|