دورية أكاديمية
Sex-specific differences in effect of prenatal exposure to dioxin-like compounds on neurodevelopment in Japanese children : Sapporo cohort study
| العنوان: | Sex-specific differences in effect of prenatal exposure to dioxin-like compounds on neurodevelopment in Japanese children : Sapporo cohort study |
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| المؤلفون: | Nakajima, Sonomi, Saijo, Yasuaki, Miyashita, Chihiro, Ikeno, Tamiko, Sasaki, Seiko, Kajiwara, Junboku, Kishi, Reiko |
| بيانات النشر: | Elsevier |
| المجموعة: | Hokkaido University Collection of Scholarly and Academic Papers (HUSCAP) / 北海道大学学術成果コレクション |
| مصطلحات موضوعية: | dioxin-like compounds, child development, prenatal exposure, background-level, sex-specific differences |
| الوقت: | 490 |
| الوصف: | BACKGROUND: Consistent reports are not available on the effects of dioxin-like polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins (PCDD)/ polychlorinated dibenzofurans (PCDF) (dioxin-like compounds [DLCs]) on child neurodevelopment. Further, the effect of background-level exposure to individual DLC isomers is not known. OBJECTIVES: We carried out the Sapporo cohort study to evaluate the effect of prenatal exposure to each DLC isomer on child neurodevelopment at 6 and 18 months of age, and assessed sex-specific differences in these effects. METHODS: The levels of all and each individual DLC isomers were estimated in maternal peripheral blood. Neurodevelopment was evaluated using the Bayley Scales of Infant Development-2nd Edition for 6-month-old infants (n = 190) and 18-month-old children (n = 121). RESULTS: In male children, levels of 10 DLC isomers were significantly negatively associated with the Psychomotor Developmental Index (PDI) at 6 months of age after adjustment for potential confounding variables. However, at 18 months of age, these associations were absent. In female children, the level of only one DLC isomer was significantly negatively associated with PDI at 6 months of age. However, in contrast to the male children, the levels of six DLC isomers in 18-month-old female children were significantly positively associated with the Mental Developmental Index. CONCLUSIONS: These findings indicate that adverse neurodevelopmental effects of prenatal background-level exposure to DLCs may be stronger in male children. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | http://hdl.handle.net/2115/75972Test; Environmental Research, 159: 222-231; http://dx.doi.org/10.1016/j.envres.2017.08.006Test |
| DOI: | 10.1016/j.envres.2017.08.006 |
| الإتاحة: | https://doi.org/10.1016/j.envres.2017.08.006Test http://hdl.handle.net/2115/75972Test |
| حقوق: | © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.6F25F7B9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.envres.2017.08.006 |
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