دورية أكاديمية
A balanced score to predict survival of elderly patients newly diagnosed with glioblastoma.
| العنوان: | A balanced score to predict survival of elderly patients newly diagnosed with glioblastoma. |
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| المؤلفون: | Straube, C., Kessel, K.A., Antoni, S., Gempt, J., Meyer, B., Schlegel, J., Schmidt-Graf, F., Combs, S.E. |
| المصدر: | Radiat. Oncol. 15:97 (2020) |
| بيانات النشر: | Bmc |
| سنة النشر: | 2020 |
| المجموعة: | PuSH - Publikationsserver des Helmholtz Zentrums München |
| مصطلحات موضوعية: | Glioblastoma, Elderly, Score, Adjuvant Treatment |
| الوصف: | BackgroundOver the past years, several treatment regimens have been recommended for elderly patients with glioblastoma (GBM), ranging from ultrahypofractionated radiotherapy (RT) over monochemotherapy (ChT) to combined radiochemotherapy (RChT). The current guidelines recommend active treatment in elderly patients in cases with a KPS of at least 60%. We established a score for selecting patients with a very poor prognosis from patients with a better prognosis.MethodsOne hundred eighty one patients >= 65years old, histologically diagnosed with GBM, were retrospectively evaluated. Clinical characteristics were analysed for their impact on the overall survival (OS). Factors which were significant in univariate analysis (log-rank test, p<0.05) were included in a multi-variate model (multi-variate Cox regression analysis, MVA). The 9-month OS for the significant factors after MVA (p <0.05) was included in a prognostic score. Score sums with a median OS of < and>6months were summarized as Group A and B, respectively.ResultsAge, KPS, MGMT status, the extent of resection, aphasia after surgery and motor dysfunction after surgery were significantly associated with OS on univariate analysis (p<0.05). On MVA age (p 0.002), MGMT promotor methylation (p 0.013) and Karnofsky performance status (p 0.005) remained significant and were included in the score. Patients were divided into two groups, group A (median OS of 2.7months) and group B (median OS of 7.8months). The score was of prognostic significance, independent of the adjuvant treatment regimen.ConclusionsThe score distinguishes patients with a poor prognosis from patients with a better prognosis. Its inclusion in future retrospective or prospective trials could help enhance the comparability of results. Before its employment on a routine basis, external validation is recommended. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1748-717X |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/32375830; info:eu-repo/semantics/altIdentifier/wos/WOS:000533922700004; info:eu-repo/semantics/altIdentifier/isbn/1748-717X; info:eu-repo/semantics; https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=59061Test; urn:isbn:1748-717X; urn:issn:1748-717X |
| DOI: | 10.1186/s13014-020-01549-9 |
| الإتاحة: | https://doi.org/10.1186/s13014-020-01549-9Test https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=59061Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.6F1861D9 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 1748717X |
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| DOI: | 10.1186/s13014-020-01549-9 |