دورية أكاديمية
Moving towards malaria elimination in southern Mozambique: Cost and cost-effectiveness of mass drug administration combined with intensified malaria control.
| العنوان: | Moving towards malaria elimination in southern Mozambique: Cost and cost-effectiveness of mass drug administration combined with intensified malaria control. |
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| المؤلفون: | Cirera, L, Galatas, B, Alonso, S, Paaijmans, K, Mamuquele, M, Martí-Soler, H, Guinovart, C, Munguambe, H, Luis, F, Nhantumbo, H, Montañà, J, Bassat, Q, Candrinho, B, Rabinovich, R, Macete, E, Aide, P, Alonso, P, Saúte, F, Sicuri, E |
| سنة النشر: | 2020 |
| المجموعة: | Queen Mary University of London: Queen Mary Research Online (QMRO) |
| مصطلحات موضوعية: | Cost-Benefit Analysis, Humans, Malaria, Mass Drug Administration, Mozambique |
| الوصف: | BACKGROUND: As new combinations of interventions aiming at interrupting malaria transmission are under evaluation, understanding the associated economic costs and benefits is critical for decision-making. This study assessed the economic cost and cost-effectiveness of the Magude project, a malaria elimination initiative implemented in a district in southern Mozambique (i.e. Magude) between August 2015-June 2018. This project piloted a combination of two mass drug administration (MDA) rounds per year for two consecutive years, annual rounds of universal indoor residual spraying (IRS) and a strengthened surveillance and response system on the back of universal long-lasting insecticide treated net (LLIN) coverage and routine case management implemented by the National Malaria Control Program (NMCP). Although local transmission was not interrupted, the project achieved large reductions in the burden of malaria in the target district. METHODS: We collected weekly economic data, estimated costs from the project implementer perspective and assessed the incremental cost-effectiveness ratio (ICER) associated with the Magude project as compared to routine malaria control activities, the counterfactual. We estimated disability-adjusted life years (DALYs) for malaria cases and deaths and assessed the variation of the ICER over time to capture the marginal costs and effectiveness associated with subsequent phases of project implementation. We used deterministic and probabilistic sensitivity analyses to account for uncertainty and built an alternative scenario by assuming the implementation of the interventions from a governmental perspective. Economic costs are provided in constant US$2015. RESULTS: After three years, the Magude project averted a total of 3,171 DALYs at an incremental cost of $2.89 million and an average yearly cost of $20.7 per targeted person. At an average cost of $19.4 per person treated per MDA round, the social mobilization and distribution of door-to-door MDA contributed to 53% of overall resources ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | e0235631 - ? |
| اللغة: | English |
| العلاقة: | PLoS One; https://qmro.qmul.ac.uk/xmlui/handle/123456789/67563Test |
| DOI: | 10.1371/journal.pone.0235631 |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0235631Test https://qmro.qmul.ac.uk/xmlui/handle/123456789/67563Test |
| حقوق: | Attribution 3.0 United States ; http://creativecommons.org/licenses/by/3.0/usTest/ |
| رقم الانضمام: | edsbas.6ED47061 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0235631 |
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