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Inhibition of the Type I Interferon Response by the Nucleoprotein of the Prototypic Arenavirus Lymphocytic Choriomeningitis Virus

التفاصيل البيبلوغرافية
العنوان: Inhibition of the Type I Interferon Response by the Nucleoprotein of the Prototypic Arenavirus Lymphocytic Choriomeningitis Virus
المؤلفون: Martínez-Sobrido, Luis, Zúñiga, Elina I., Rosario, Debralee, García-Sastre, Adolfo, de la Torre, Juan Carlos
المصدر: Journal of Virology ; volume 80, issue 18, page 9192-9199 ; ISSN 0022-538X 1098-5514
بيانات النشر: American Society for Microbiology
سنة النشر: 2006
الوصف: The prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) is a formidable battle horse for the study of viral immunology, as well as viral persistence and associated diseases. Investigations with LCMV have uncovered basic mechanisms by which viruses avoid elimination by the host adaptive immune response. In this study we show that LCMV also disables the host innate defense by interfering with beta interferon (IFN-β) production in response to different stimuli, including infection with Sendai virus and liposome-mediated DNA transfection. Inhibition of IFN production in LCMV-infected cells was caused by an early block in the IFN regulatory factor 3 (IRF-3) activation pathway. This defect was restored in cells cured of LCMV, indicating that one or more LCMV products are responsible for the inhibition of IRF-3 activation. Using expression plasmids encoding individual LCMV proteins, we found that expression of the LCMV nucleoprotein (NP) was sufficient to inhibit both IFN production and nuclear translocation of IRF-3. To our knowledge, this is the first evidence of an IFN-counteracting viral protein in the Arenaviridae family. Inhibition of IFN production by the arenavirus NP is likely to be a determinant of virulence in vivo.
نوع الوثيقة: article in journal/newspaper
اللغة: English
DOI: 10.1128/jvi.00555-06
DOI: 10.1128/JVI.00555-06
الإتاحة: https://doi.org/10.1128/jvi.00555-06Test
حقوق: https://journals.asm.org/non-commercial-tdm-licenseTest
رقم الانضمام: edsbas.6E54892B
قاعدة البيانات: BASE
الوصف
DOI:10.1128/jvi.00555-06