دورية أكاديمية
SUMOylation modulates eIF5A activities in both yeast and pancreatic ductal adenocarcinoma cells
| العنوان: | SUMOylation modulates eIF5A activities in both yeast and pancreatic ductal adenocarcinoma cells |
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| المؤلفون: | Seoane, Rocío, Lama-Díaz, Tomás, Romero, Antonia María, El Motiam, Ahmed, Martínez-Férriz, Arantxa, Vidal, Santiago, Bouzaher, Yanis H., Blanquer, María, Tolosa, Rocío M., Castillo Mewa, Juan, Álvarez-Rodríguez, Manuel, García-Sastre, Adolfo, Xirodimas, Dimitris, Sutherland, James D., Barrio, Rosa, Alepuz, Paula, Blanco, Miguel G., Farràs, Rosa, Rivas, Carmen |
| المساهمون: | Conferencia de Rectores de las Universidades Españolas, Consejo Superior de Investigaciones Científicas (España), European Commission, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Ciencia e Innovación (España), Xunta de Galicia, Generalitat Valenciana, Banco Santander, Universidad de Santiago de Compostela, Instituto de Salud Carlos III, Asociación Española Contra el Cáncer |
| بيانات النشر: | BioMed Central |
| سنة النشر: | 2024 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | Pancreatic ductal adenocarcinoma, SUMO2, Stress granules, Stress response, eIF5A |
| الوصف: | The eukaryotic translation initiation protein eIF5A is a highly conserved and essential factor that plays a critical role in different physiological and pathological processes including stress response and cancer. Different proteomic studies suggest that eIF5A may be a small ubiquitin-like modifier (SUMO) substrate, but whether eIF5A is indeed SUMOylated and how relevant is this modification for eIF5A activities are still unknown. ; Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. Funding at the laboratory of CR is provided by Ministry of Science, Innovation and Universities and FEDER (BFU-2017-88880-P), (PID2021-126510NB-I00), and Xunta de Galicia (ED431G 2023/10). RS, SV and TLD are predoctoral fellows funded by Xunta de Galicia-Consellería de Cultura, Educación y Ordenación Universitaria (ED481A-2020/160, ED481A-2018/110, and ED481A-2018/042, respectively). AMR is a postdoctoral funded by Generalitat Valenciana (CIAPOS2021/117). MB is a predoctoral fellow funded by Banco Santander and University of Santiago de Compostela. RMT is a predoctoral fellow funded by Instituto de Investigación Sanitaria de Santiago de Compostela. The Blanco lab is supported by MCIN/AEI/https://doi.org/10.13039/501100011033Test [PID2020-115472 GB-I00] and Xunta de Galicia/ FEDER ‘Una manera de hacer Europa’ [ED431C 2019/013]. RF lab is supported by Fondo de Investigación Sanitaria, ISCIII (PI20-00194). PA lab is supported by MCIN/AEI/https://doi.org/10.13039/501100011033Test (PID2020-120066RB-I00) and by GVA CIAICO/2022/237. AMF is a predoctoral fellow funded by Asociación Española Contra el Cáncer (AECC APRO 2018). RB and JDS thank MCIN/AEI/https://doi.org/10.13039/501100011033Test (PID2020-114178 GB-I00, CEX2021-001136-S). CR, RF and RB acknowledge SAF2017-90900-REDT support (UBIRed Program, Spain) and COST Action ProteoCure CA20113. ; Peer reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1689-1392 |
| العلاقة: | #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-126510NB-I00/ES/PROTEINAS TIPO UBIQUITINA EN LA INTERACCION VIRUS-CELULA/; info:eu-repo/grantAgreement/AEI//BFU-2017-88880-P; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-115472GB-I00/ES/REGULACION DE RESOLVASAS Y HELICASAS EN EL PROCESADO DE ESTRUCTURAS SECUNDARIAS DEL ADN/; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-120066RB-I00/ES/FUNCION DEL FACTOR DE ELONGACION DE LA TRADUCCION EIF5A EN EL METABOLISMO DE MRNAS Y EN LA PRODUCCION DE COLAGENO DURANTE EL CIERRE DE HERIDAS, EN COLAGENOPATIAS Y EN FIBROSIS/; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-114178GB-I00/ES/HOMEOSTASIS DE PROTEINAS EN EL DESARROLLO Y LA ENFERMEDAD: INTERACCION DE FACTORES UBIQUITINA-LIKE Y SALL EN CILIOGENESIS/; info:eu-repo/grantAgreement/AEI//CEX2021-001136-S; Publisher's version; The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.1186/s11658-024-00533-5Test; https://doi.org/10.1186/s11658-024-00533-5Test; Sí; Cellular and Molecular Biology Letters 29: 15 (2024); CEX2021-001136-S; http://hdl.handle.net/10261/358896Test |
| DOI: | 10.1186/s11658-024-00533-5 |
| الإتاحة: | https://doi.org/10.1186/s11658-024-00533-5Test http://hdl.handle.net/10261/358896Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.6E0A262B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16891392 |
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| DOI: | 10.1186/s11658-024-00533-5 |