دورية أكاديمية
Protective effect of Allium scorodoprasum L. ethanolic extract in cyclophosphamide-induced hepatotoxicity model in rats
| العنوان: | Protective effect of Allium scorodoprasum L. ethanolic extract in cyclophosphamide-induced hepatotoxicity model in rats |
|---|---|
| المؤلفون: | Güngör, Hüseyin, Ekici, Mehmet, Karataş, Özhan, Dik, Burak |
| المساهمون: | Veteriner Fakültesi, orcid:0000-0002-2778-8059 |
| سنة النشر: | 2023 |
| المجموعة: | Sivas Cumhuriyet University Institutional Repository |
| مصطلحات موضوعية: | Allium scorodoprasum extract, cyclophosphamide, inflammation, liver toxicity, oxidative stress |
| الوصف: | Objectives Cyclophosphamide is a chemotherapeutic agent and immunosuppressant drug; however, it damages the liver. This study investigates the protective effect of ethanolic extract of Allium scorodoprasum (ASE) on cyclophosphamide-induced liver injury. Methods Twenty-eight Wistar albino rats were randomly divided into four groups (n = 7 per group): healthy rats, cyclophosphamide (200 mg/kg), cyclophosphamide (200 mg/kg) + ASE (100 mg/kg) and cyclophosphamide (200 mg/kg) + ASE (200 mg/kg). ASE was administered for 14 days, and the rats were euthanized 24 h after cyclophosphamide administration. Key findings Cyclophosphamide treatment leads to an increase in serum levels of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, total cholesterol, triglycerides, low-density lipoprotein and very low-density lipoprotein, as well as an increase in the liver levels of malondialdehyde, tumour necrosis factor, interleukin (IL)-1β and IL-6, while high-density lipoprotein levels decrease. Treatment with cyclophosphamide caused liver necrosis and postnecrotic cell infiltration; however, pathological changes were prevented by ASE. 8-Hydroxy-2ʹ- deoxyguanosine, anti-4-hydroxynenal antibody and anti-dityrosine levels increased in rats treated with cyclophosphamide and decreased in the groups treated with ASE. These changes were dose dependent in the ASE-treated groups. Conclusions Treatment with cyclophosphamide caused liver damage due to oxidative stress and inflammation. ASE regulated the damage at high doses because it has potent antioxidant and anti-inflammatory ingredients. In future studies, it may be beneficial to administer ASE in higher doses or for longer periods of time. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Uluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanı; https://hdl.handle.net/20.500.12418/14809Test |
| الإتاحة: | https://doi.org/20.500.12418/14809Test https://hdl.handle.net/20.500.12418/14809Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.6DF35E87 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |