دورية أكاديمية
Physical activity counteracted associations of exposure to mixture of air pollutants with mitochondrial DNA copy number among rural Chinese adults
| العنوان: | Physical activity counteracted associations of exposure to mixture of air pollutants with mitochondrial DNA copy number among rural Chinese adults |
|---|---|
| المؤلفون: | Li, R, Li, S, Pan, M, Chen, H, Liu, X, Chen, G, Chen, R, Yin, S, Hu, K, Mao, Z, Huo, W, Wang, X, Yu, S, Guo, Y, Hou, J, Wang, C |
| المساهمون: | Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. |
| المصدر: | 272 ; 129907 |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2021 |
| المجموعة: | University of Wolverhampton: Wolverhampton Intellectual Repository and E-Theses (WIRE) |
| مصطلحات موضوعية: | air pollutants, physical activity, mitochondrial DNA copy number, rural population, quantile g-computation, Humans, Nitrogen Dioxide, DNA, Mitochondrial, Exercise, Cohort Studies, Air Pollution, Environmental Exposure, Adult, China, Particulate Matter, DNA Copy Number Variations |
| الوصف: | This is an accepted manuscript of a paper published by Elsevier on 15/02/2021, available online at: https://doi.org/10.1016/j.chemosphere.2021.129907Test The accepted manuscript of the publication may differ from the final published version. ; Background: Exposure to single air pollutant and physical activity (PA) were associated with an altered mitochondrial DNA copy number (mtDNA-CN). However, studies on the interactive effects of single or a mixture of air pollutants and PA on mtDNA-CN were limited. Methods: A total of 2707 Chinese adults were obtained from the Henan Rural Cohort Study. Spatiotemporal models were used to estimate particulate matter (PMs) (PM with an aerodynamic diameter ≤ 1.0 μm (PM1), ≤2.5 μm (PM2.5) or ≤ 10 μm (PM10)) and nitrogen dioxide (NO2) concentrations. Relative mtDNA-CN was measured by quantitative real-time polymerase chain reaction. Linear regression and quantile g-computation models were applied to examine associations of single or mixture of air pollutants with relative mtDNA-CN. The interactive effects of single or mixture of air pollutants and PA on relative mtDNA-CN were visualized by using Interaction plots. Results: Each 1 μg/m3 increment in PM1, PM2.5, PM10 or NO2 was associated with a 5.11% (95% confidence interval: 3.71%, 6.53%), 6.77% (4.81%, 8.76%), 3.05% (2.22%, 3.87%) or 4.99% (3.45%, 6.55%) increase in relative mtDNA-CN. Each one-quartile increment in mixture of the four air pollutants was related to a 0.053 (0.032, 0.075) increase in relative mtDNA-CN. Negative interaction effects of single or mixture of air pollutants and PA on relative mtDNA-CN were observed. Conclusions: The positive associations of single or mixture of air pollutants with relative mtDNA-CN were counteracted by PA at certain levels, implying that PA may be a costless and effective approach to decrease negative effects of air pollution on mtDNA-CN. ; Published version |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0045-6535 1879-1298 |
| العلاقة: | https://www.sciencedirect.com/science/article/abs/pii/S0045653521003763?via%3DihubTest; Li, R., Li, S., Pan, M. et al. (2021) Physical activity counteracted associations of exposure to mixture of air pollutants with mitochondrial DNA copy number among rural Chinese adults. Chemosphere, 272, 129907.; 33601207 (pubmed); http://hdl.handle.net/2436/624688Test; Chemosphere |
| DOI: | 10.1016/j.chemosphere.2021.129907 |
| الإتاحة: | https://doi.org/10.1016/j.chemosphere.2021.129907Test http://hdl.handle.net/2436/624688Test |
| رقم الانضمام: | edsbas.6DCFA249 |
| قاعدة البيانات: | BASE |
| تدمد: | 00456535 18791298 |
|---|---|
| DOI: | 10.1016/j.chemosphere.2021.129907 |