دورية أكاديمية
Intrauterine Exposure to Antidepressants or Maternal Depressive Symptoms and Offspring Brain White Matter Trajectories From Late Childhood to Adolescence
| العنوان: | Intrauterine Exposure to Antidepressants or Maternal Depressive Symptoms and Offspring Brain White Matter Trajectories From Late Childhood to Adolescence |
|---|---|
| المؤلفون: | Koc, Dogukan, El Marroun, Hanan, Stricker, Bruno H., Muetzel, Ryan L., Tiemeier, Henning |
| المصدر: | Koc , D , El Marroun , H , Stricker , B H , Muetzel , R L & Tiemeier , H 2024 , ' Intrauterine Exposure to Antidepressants or Maternal Depressive Symptoms and Offspring Brain White Matter Trajectories From Late Childhood to Adolescence ' , Biological Psychiatry: Cognitive Neuroscience and Neuroimaging , vol. 9 , no. 2 , pp. 217-226 . https://doi.org/10.1016/j.bpsc.2023.10.009Test |
| سنة النشر: | 2024 |
| الوصف: | Background: During pregnancy, both selective serotonin reuptake inhibitor (SSRI) exposure and maternal depression have been associated with poor offspring neurodevelopmental outcomes. In a population-based cohort, we investigated the association between intrauterine exposure to SSRIs and depressive symptoms and offspring white matter development from childhood to adolescence. Methods: Self-reported SSRI use was verified by pharmacy records. In midpregnancy, women reported on depressive symptoms using the Brief Symptom Inventory. Using diffusion tensor imaging, offspring white matter microstructure, including whole-brain and tract-specific fractional anisotropy (FA) and mean diffusivity, was measured at 3 assessments between ages 7 to 15 years. The participants were divided into 4 groups: prenatal SSRI exposure (n = 37 with 60 scans), prenatal depression exposure (n = 229 with 367 scans), SSRI use before pregnancy (n = 72 with 95 scans), and reference (n = 2640 with 4030 scans). Results: Intrauterine exposure to SSRIs and depressive symptoms were associated with lower FA in the whole-brain and the forceps minor at 7 years. Exposure to higher prenatal depressive symptom scores was associated with lower FA in the uncinate fasciculus, cingulum bundle, superior and inferior longitudinal fasciculi, and corticospinal tracts. From ages 7 to 15 years, children exposed to prenatal depressive symptoms showed a faster increase in FA in these white matter tracts. Prenatal SSRI exposure was not related to white matter microstructure growth over and above exposure to depressive symptoms. Conclusions: These results suggest that prenatal exposure to maternal depressive symptoms was negatively associated with white matter microstructure in childhood, but these differences attenuated during development, suggesting catch-up growth. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://pure.eur.nl/en/publications/84916d85-e138-4583-b576-3f24291685a7Test |
| DOI: | 10.1016/j.bpsc.2023.10.009 |
| الإتاحة: | https://doi.org/10.1016/j.bpsc.2023.10.009Test https://pure.eur.nl/en/publications/84916d85-e138-4583-b576-3f24291685a7Test https://pure.eur.nl/ws/files/123620368/Intrauterine_Exposure_to_Antidepressants_or_Maternal_Depressive_Symptoms_and_Offspring_Brain_White_Matter_Trajectories_From_Late_Childhood_to_Adolescence.pdfTest http://www.scopus.com/inward/record.url?scp=85180297791&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.6D77B696 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.bpsc.2023.10.009 |
|---|