دورية أكاديمية
Target 2035-update on the quest for a probe for every protein
العنوان: | Target 2035-update on the quest for a probe for every protein |
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المؤلفون: | Mueller, S, Ackloo, S, Al Chawaf, A, Al-Lazikani, B, Antolin, A, Baell, JB, Beck, H, Beedie, S, Betz, UAK, Bezerra, GA, Brennan, PE, Brown, D, Brown, PJ, Bullock, AN, Carter, AJ, Chaikuad, A, Chaineau, M, Ciulli, A, Collins, I, Dreher, J, Drewry, D, Edfeldt, K, Edwards, AM, Egner, U, Frye, S, Fuchs, SM, Hall, MD, Hartung, I, Hillisch, A, Hitchcock, SH, Homan, E, Kannan, N, Kiefer, JR, Knapp, S, Kostic, M, Kubicek, S, Leach, AR, Lindemann, S, Marsden, BD, Matsui, H, Meier, JL, Merk, D, Michel, M, Morgan, MR, Mueller-Fahrnow, A, Owen, DR, Perry, BG, Rosenberg, SH, Saikatendu, KS, Schapira, M, Scholten, C, Sharma, S, Simeonov, A, Sundstrom, M, Superti-Furga, G, Todd, MH, Tredup, C, Vedadi, M, von Delft, F, Willson, TM, Winter, GE, Workman, P, Arrowsmith, CH |
المصدر: | RSC Medicinal Chemistry (2021) |
بيانات النشر: | ROYAL SOC CHEMISTRY |
سنة النشر: | 2021 |
المجموعة: | University College London: UCL Discovery |
مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Chemistry, Medicinal, Pharmacology & Pharmacy, DRUG DISCOVERY |
الوصف: | Twenty years after the publication of the first draft of the human genome, our knowledge of the human proteome is still fragmented. The challenge of translating the wealth of new knowledge from genomics into new medicines is that proteins, and not genes, are the primary executers of biological function. Therefore, much of how biology works in health and disease must be understood through the lens of protein function. Accordingly, a subset of human proteins has been at the heart of research interests of scientists over the centuries, and we have accumulated varying degrees of knowledge about approximately 65% of the human proteome. Nevertheless, a large proportion of proteins in the human proteome (∼35%) remains uncharacterized, and less than 5% of the human proteome has been successfully targeted for drug discovery. This highlights the profound disconnect between our abilities to obtain genetic information and subsequent development of effective medicines. Target 2035 is an international federation of biomedical scientists from the public and private sectors, which aims to address this gap by developing and applying new technologies to create by year 2035 chemogenomic libraries, chemical probes, and/or biological probes for the entire human proteome. |
نوع الوثيقة: | article in journal/newspaper |
وصف الملف: | text |
اللغة: | English |
العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10140551/1/d1md00228g.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10140551Test/ |
الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10140551/1/d1md00228g.pdfTest https://discovery.ucl.ac.uk/id/eprint/10140551Test/ |
حقوق: | open |
رقم الانضمام: | edsbas.6CBAC4F6 |
قاعدة البيانات: | BASE |
الوصف غير متاح. |