دورية أكاديمية
COMPANION-002 A clinical trial of investigational drug CTX-009 plus paclitaxel vs paclitaxel in second line advanced BTC.
| العنوان: | COMPANION-002 A clinical trial of investigational drug CTX-009 plus paclitaxel vs paclitaxel in second line advanced BTC. |
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| المؤلفون: | Azad, Nilofer, Hu, Zishuo, Sahin, Ilyas, Iyer, Renuka, Aranha, Olivia, Hochster, Howard, Pathak, Priyadarshini, Paulson, Andrew Scott, Kalyan, Aparna, Liao, Chih-Yi, Tran, Nguyen, Kelley, Robin K, Heestand, Gregory, Cosgrove, David, El-Khoueiry, Anthony, Borad, Mitesh, Gabrail, Nashat Y, Majeed, Umair, Du, Lingling, Kamath, Suneel, Shumway, Nathan, Shroff, Rachna, Goyal, Lipika, Rosales, Minori, Javle, Milind |
| المصدر: | Future Oncol ; ISSN:1744-8301 |
| بيانات النشر: | Atypon |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | CTX-009, DLL4, Paclitaxel, VEGF, anti-angiogenesis, biliary tract cancer, cholangiocarcinoma, clinical trial |
| الوصف: | Treatment options for patients with biliary tract cancer are limited, and the prognosis is poor. CTX-009, a novel bispecific antibody targeting both DLL4 and VEGF-A, has demonstrated antitumor activity in patients with advanced cancers as both a monotherapy and in combination with chemotherapy. In a phase II study of patients with advanced biliary tract cancer who had received one or two prior therapies, CTX-009 with paclitaxel demonstrated a 37.5% overall response rate (ORR). Described here is the design of and rationale for COMPANION-002, a randomized phase II/III study, which will evaluate the safety and efficacy of CTX-009 in combination with paclitaxel versus paclitaxel alone as second-line treatment for patients with advanced biliary tract cancer. The primary end point is ORR, and crossover is allowed.Clinical Trial Registration: NCT05506943 (ClinicalTrials.gov). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1080/14796694.2024.2351351Test; https://pubmed.ncbi.nlm.nih.gov/38861293Test |
| DOI: | 10.1080/14796694.2024.2351351 |
| الإتاحة: | https://doi.org/10.1080/14796694.2024.2351351Test https://pubmed.ncbi.nlm.nih.gov/38861293Test |
| رقم الانضمام: | edsbas.6C910AB5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1080/14796694.2024.2351351 |
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