دورية أكاديمية
Anti-heart and anti-intercalated disk autoantibodies: evidence for autoimmunity in idiopathic recurrent acute pericarditis
| العنوان: | Anti-heart and anti-intercalated disk autoantibodies: evidence for autoimmunity in idiopathic recurrent acute pericarditis |
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| المؤلفون: | Caforio, A L P, Brucato, A, Doria, A, Brambilla, G, Angelini, A, Ghirardello, A, Bottaro, S, Tona, F, Betterle, C, Daliento, L, Thiene, G, Iliceto, S |
| بيانات النشر: | BMJ Publishing Group Ltd |
| سنة النشر: | 2010 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Pericardial disease |
| الوصف: | Background Idiopathic recurrent acute pericarditis (IRAP) is a rare disease of suspected, yet unproved, immune-mediated origin. The finding of serum heart-specific autoantibodies in IRAP would strengthen the autoimmune hypothesis and provide aetiology-specific non-invasive biomarkers. Objective To assess frequency of serum anti-heart (AHA), anti-intercalated-disk (AIDA) and non-cardiac-specific autoantibodies and their clinical and instrumental correlates in patients with IRAP. Patients 40 consecutive patients with IRAP, 25 male, aged 37±16 years, representing a large single-centre cohort collected at a referral centre over a long time period (median 5 years, range 1–22 years). Control groups included patients with non-inflammatory cardiac disease (NICD) (n=160), ischaemic heart failure (n=141) and normal subjects (n=270). Methods AHA (organ-specific, cross-reactive 1 and 2 types) and AIDA were detected in serum samples from patients, at last follow-up, and control subjects by indirect immunofluorescence (IIF) on human myocardium and skeletal muscle. Non-cardiac-specific autoantibodies were detected by IIF, and anti-Ro/SSA, anti-La/SSB by ELISA. Results The frequencies of cross-reactive 1 AHA and of AIDA were higher (50%; 25%) in IRAP than in NICD (4%; 4%), ischaemic (1%; 2%) or normal subjects (3%; 0%) (p=0.0001). AHA and/or AIDA were found in 67.5% patients with IRAP. Of the non-cardiac-specific antibodies, only antinuclear autoantibodies at titre ≥1/160 were more common in IRAP (5%) versus normal (0.5%, p<0.04). AIDA in IRAP were associated with a higher number of recurrences (p=0.01) and hospitalisations (p=0.0001), high titre (1/80 or higher) AHA with a higher number of recurrences (p=0.02). Conclusions The detection of AHA and of AIDA supports the involvement of autoimmunity in the majority of patients with IRAP. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://heart.bmj.com/cgi/content/short/96/10/779Test; http://dx.doi.org/10.1136/hrt.2009.187138Test |
| DOI: | 10.1136/hrt.2009.187138 |
| الإتاحة: | https://doi.org/10.1136/hrt.2009.187138Test http://heart.bmj.com/cgi/content/short/96/10/779Test |
| حقوق: | Copyright (C) 2010, BMJ Publishing Group Ltd |
| رقم الانضمام: | edsbas.6C6E5766 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/hrt.2009.187138 |
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