التفاصيل البيبلوغرافية
| العنوان: |
Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria |
| المؤلفون: |
Rosain, Jérémie, Neehus, Anna-Lena, Manry, Jérémy, Yang, Rui, Le Pen, Jérémie, Daher, Wassim, Liu, Zhiyong, Chan, Yi-Hao, Tahuil, Natalia, Türel, Özden, Bourgey, Mathieu, Ogishi, Masato, Doisne, Jean-Marc, Izquierdo, Helena M, Shirasaki, Takayoshi, Le Voyer, Tom, Guérin, Antoine, Bastard, Paul, Moncada-Vélez, Marcela, Han, Ji Eun, Khan, Taushif, Rapaport, Franck, Hong, Seon-Hui, Cheung, Andrew, Haake, Kathrin, Mindt, Barbara C, Pérez, Laura, Philippot, Quentin, Lee, Danyel, Zhang, Peng, Rinchai, Darawan, Al Ali, Fatima, Ahmad Ata, Manar Mahmoud, Rahman, Mahbuba, Peel, Jessica N, Heissel, Søren, Molina, Henrik, Kendir-Demirkol, Yasemin, Bailey, Rasheed, Zhao, Shuxiang, Bohlen, Jonathan, Seeleuthner, Yoann, Roelens, Marie, Lorenzo, Lazaro, Soudée, Camille, Paz, María Elvira Josefina, González, María Laura, Jeljeli, Mohamed, Soulier, Jean, Romana, Serge, L'Honneur, Anne-Sophie, Materna, Marie, Martínez-Barricarte, Rubén, Pochon, Mathieu, Oleaga-Quintas, Carmen, Michev, Alexandre, Migaud, Mélanie, Lévy, Romain, Alyanakian, Marie-Alexandra, Rozenberg, Flore, Croft, Carys A, Vogt, Guillaume, Emile, Jean-François, Kremer, Laurent, Ma, Cindy S, Fritz, Jörg H, Lemon, Stanley M, Spaan, András N, Manel, Nicolas, Abel, Laurent, MacDonald, Margaret R, Boisson-Dupuis, Stéphanie, Marr, Nico, Tangye, Stuart G, Di Santo, James P, Zhang, Qian, Zhang, Shen-Ying, Rice, Charles M, Béziat, Vivien, Lachmann, Nico, Langlais, David, Casanova, Jean-Laurent, Gros, Philippe, Bustamante, Jacinta |
| المساهمون: |
Infection & Immunity, MMB Medische Staf |
| سنة النشر: |
2023 |
| مصطلحات موضوعية: |
COVID-19, Child, Humans, Interferon Regulatory Factor-1, Interferon-alpha, Interferon-gamma, Mycobacterium, SARS-CoV-2, Journal Article, Research Support, N.I.H., Extramural, Non-U.S. Gov't |
| الوصف: |
Inborn errors of human IFN-γ-dependent macrophagic immunity underlie mycobacterial diseases, whereas inborn errors of IFN-α/β-dependent intrinsic immunity underlie viral diseases. Both types of IFNs induce the transcription factor IRF1. We describe unrelated children with inherited complete IRF1 deficiency and early-onset, multiple, life-threatening diseases caused by weakly virulent mycobacteria and related intramacrophagic pathogens. These children have no history of severe viral disease, despite exposure to many viruses, including SARS-CoV-2, which is life-threatening in individuals with impaired IFN-α/β immunity. In leukocytes or fibroblasts stimulated in vitro, IRF1-dependent responses to IFN-γ are, both quantitatively and qualitatively, much stronger than those to IFN-α/β. Moreover, IRF1-deficient mononuclear phagocytes do not control mycobacteria and related pathogens normally when stimulated with IFN-γ. By contrast, IFN-α/β-dependent intrinsic immunity to nine viruses, including SARS-CoV-2, is almost normal in IRF1-deficient fibroblasts. Human IRF1 is essential for IFN-γ-dependent macrophagic immunity to mycobacteria, but largely redundant for IFN-α/β-dependent antiviral immunity. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
0092-8674 |
| العلاقة: |
https://dspace.library.uu.nl/handle/1874/451282Test |
| الإتاحة: |
https://dspace.library.uu.nl/handle/1874/451282Test |
| حقوق: |
info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: |
edsbas.6C46BB3D |
| قاعدة البيانات: |
BASE |
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