دورية أكاديمية
Lack of indinavir-associated nephrological complications in HIV-infected adults (predominantly women) with high indinavir plasma concentration in Abidjan, Côte d'Ivoire.
| العنوان: | Lack of indinavir-associated nephrological complications in HIV-infected adults (predominantly women) with high indinavir plasma concentration in Abidjan, Côte d'Ivoire. |
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| المؤلفون: | Danel, Christine, Moh, Raoul, Peytavin, Gilles, Anzian, Amani, Minga, Albert, K., Gomis, Olivier Ba, Seri, Boga, Nzunettu, Gustave, Gabillard, Delphine, Salamon, Roger, Bissagnene, Emmanuel, Anglaret, Xavier |
| المساهمون: | Programme PAC-CI, ANRS France Recherche Nord & sud Sida-hiv hépatites, Service de Pharmacologie Clinique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Epidémiologie, santé publique et développement, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des Maladies Infectieuses et Tropicales (SMIT), CHU de Treichville |
| المصدر: | ISSN: 0889-2229. |
| بيانات النشر: | HAL CCSD Mary Ann Liebert |
| سنة النشر: | 2007 |
| المجموعة: | Inserm: HAL (Institut national de la santé et de la recherche médicale) |
| مصطلحات موضوعية: | MESH: Cohort Studies, MESH: Indinavir, MESH: Male, MESH: RNA, Viral, MESH: Retrospective Studies, MESH: Time Factors, MESH: Treatment Outcome, MESH: Viral Load, MESH: Adult, MESH: Cote d'Ivoire, MESH: Female, MESH: Follow-Up Studies, MESH: HIV Infections, MESH: HIV Protease Inhibitors, MESH: HIV-1, MESH: HIV-2, MESH: Humans, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases |
| الوصف: | International audience ; To report the tolerance of indinavir combined with ritonavir (IDV/r 800/100 mg) twice daily (bid) in sub-Saharan African HIV-infected adults. HAART-naives patients started zidovudine plus lamivudine plus IDV/r 800/100 mg bid. Follow-up included standardized documentation of morbidity, CD4(+) cell count, creatininemia, plasma HIV-1 RNA, and IDV minimal plasma concentration (C(min)) measurements at month 1 (M1), M3, and M6. Seventy HIV-1-infected adults (68 women, median CD4 235/mm(3)) started HAART. At M6, 63% had undetectable viral load, and the median gain in CD4 since baseline was +128/mm(3). During the first 6 months, 21 patients experimented with 23 treatment modifications (reduction in IDV/r 400/100 mg bid, n = 11; switch to efavirenz, n = 11; zidovudine replaced by stavudine, n = 1), including 22 for digestive intolerance and 1 for severe anemia. At M1, M3, and M6, 67, 59, and 48 patients were still receiving IDV/r 800/100 mg bid, of whom 70%, 72%, and 60% had IDV Cmin above 5 ng/ml, respectively. In these patients, at M1, M3, and M6, the mean (+/- SD) IDV C(min) were 3431 +/- 3835 ng/ml, 2288 +/- 2116 ng/ml, and 1543 +/- 2398 ng/ml, respectively. There was no renal insufficiency of any grade, and no symptoms of urinary stones. The IDV/r 800/100 mg bid-containing regimen led to high IDV Cmin and a high rate of digestive intolerance. There was a surprising lack of nephrological side effects during the 6 months of follow-up, supporting the hypothesis that nephrological tolerance of IDV might be higher in sub-Saharan African individuals than in Americans or Europeans. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/17263634; inserm-00173523; https://inserm.hal.science/inserm-00173523Test; https://inserm.hal.science/inserm-00173523/documentTest; https://inserm.hal.science/inserm-00173523/file/inserm-00173523_edited.pdfTest; https://inserm.hal.science/inserm-00173523/file/Danel_Indinavir_nephrological_complications_in_Africa_AIDS_Res_Hum_Retrovir_2007_in_press.pdfTest; PUBMED: 17263634 |
| DOI: | 10.1089/aid.2006.0038 |
| الإتاحة: | https://doi.org/10.1089/aid.2006.0038Test https://inserm.hal.science/inserm-00173523Test https://inserm.hal.science/inserm-00173523/documentTest https://inserm.hal.science/inserm-00173523/file/inserm-00173523_edited.pdfTest https://inserm.hal.science/inserm-00173523/file/Danel_Indinavir_nephrological_complications_in_Africa_AIDS_Res_Hum_Retrovir_2007_in_press.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.6BD77CB4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1089/aid.2006.0038 |
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