دورية أكاديمية
Circulating cytokine dynamics as potential biomarker of response to anti-PD-1 immunotherapy in BRAFwt MM patients
| العنوان: | Circulating cytokine dynamics as potential biomarker of response to anti-PD-1 immunotherapy in BRAFwt MM patients |
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| المؤلفون: | Katarina Mirjačić Martinović, Ana Vuletić, Nevena Tišma Miletić, Irina Besu Žižak, Jelena Milovanović, Suzana Matković, Vladimir Jurišić |
| المصدر: | Translational Oncology, Vol 38, Iss , Pp 101799- (2023) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Metastatic melanoma patients, BRAF wild type, Pembrolizumab, Cytokines, Monitoring, Outcome predictors, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Background: The biomarkers of immune checkpoint inhibitors (ICIs) efficacy and safety are still urgently needed. As cytokines are easily detected and monitored in circulation, they could be used as potential predictors of response and immune-related adverse events (irAEs) for ICIs therapy. Methods: The levels of TGF-β, IFN-γ, IL-6, IL-8, IL-10 were measured in sera and plasma by ELISA method of 30 healthy controls (HC) and 32 BRAF wild type (wt) MM patients before and after every 12 weeks of Pembrolizumab, PD-1 inhibitor, until one year or disease progression (DP). Results: Higher pretherapy levels of circulating TGF-β, IFN-γ, IL-6, and IL-10 were shown in MM patients compared to HC. In patients with disease control, TGF-β and IL-6 first decreased during the therapy, while then they started to successively increase reaching the initial values by the end of the follow up. Furthermore, in this group of patients IFN-γ increased, while IL-8 and IL-10 decreased at final points of the follow up. In patients with DP IL-6 increased at the time of progression, while IL-8 decreased when the best response was achieved. In patients with pseudoprogression IL-6 and IL-10 significantly increased compared to the pretreatment values. Melanoma patients with irAEs had increased baseline values of TGF-β, IFN-γ, IL-6, and IL-10 compared to HC. However, no significant changes in cytokines levels were found in these patients during therapy. Conclusions: Inflammatory cytokines monitoring in circulation of BRAFwt MM patients could help in the selection of patients who will have the benefit from Pembrolizumab therapy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1936-5233 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S1936523323001857Test; https://doaj.org/toc/1936-5233Test; https://doaj.org/article/c68b01a901b24440bc1d7b0973b2c6f9Test |
| DOI: | 10.1016/j.tranon.2023.101799 |
| الإتاحة: | https://doi.org/10.1016/j.tranon.2023.101799Test https://doaj.org/article/c68b01a901b24440bc1d7b0973b2c6f9Test |
| رقم الانضمام: | edsbas.6BC369AB |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19365233 |
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| DOI: | 10.1016/j.tranon.2023.101799 |