دورية أكاديمية
Multicentric experience with interferon gamma therapy in sepsis induced immunosuppression. A case series
| العنوان: | Multicentric experience with interferon gamma therapy in sepsis induced immunosuppression. A case series |
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| المؤلفون: | Payen, Didier, Faivre, Valerie, Miatello, Jordi, Leentjens, Jenneke, Brumpt, Caren, Tissières, Pierre, Dupuis, Claire, Pickkers, Peter, Lukaszewicz, Anne Claire |
| المساهمون: | Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Ecotaxie, microenvironnement et développement lymphocytaire (EMily (UMR_S_1160 / U1160)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Bicêtre Hospital, Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Radboud University Medical Center Nijmegen, Hôpital Lariboisière-Fernand-Widal APHP, Endotoxines, Structures et Réponses de l'hôte (ESHR), Département Microbiologie (Dpt Microbio), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 1471-2334 ; BMC Infectious Diseases ; https://hal.science/hal-02359951Test ; BMC Infectious Diseases, 2019, 19 (1), pp.931. ⟨10.1186/s12879-019-4526-x⟩ ; https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-019-4526-xTest. |
| بيانات النشر: | HAL CCSD BioMed Central |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Cytokines, Immuno-depression, Interferon gamma, Lymphocyte immuno-phenotyping, MHC class II, Sepsis, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; BACKGROUND: The sepsis-induced immunodepression contributes to impaired clinical outcomes of various stress conditions. This syndrome is well documented and characterized by attenuated function of innate and adaptive immune cells. Several pharmacological interventions aimed to restore the immune response are emerging of which interferon-gamma (IFNγ) is one. It is of paramount relevance to obtain clinical information on optimal timing of the IFNγ-treatment, -tolerance, -effectiveness and outcome before performing a RCT. We describe the effects of IFNγ in a cohort of 18 adult and 2 pediatric sepsis patients. METHODS: In this open-label prospective multi-center case-series, IFNγ treatment was initiated in patients selected on clinical and immunological criteria early (\textless 4 days) or late (\textgreater 7 days) following the onset of sepsis. The data collected in 18 adults and 2 liver transplanted pediatric patients were: clinical scores, monocyte expression of HLA-DR (flow cytometry), lymphocyte immune-phenotyping (flow cytometry), IL-6 and IL-10 plasma levels (ELISA), bacterial cultures, disease severity, and mortality. RESULTS: In 15 out of 18 patients IFNγ treatment was associated with an increase of median HLA-DR expression from 2666 [IQ 1547; 4991] to 12,451 [IQ 4166; 19,707], while the absolute number of lymphocyte subpopulations were not affected, except for the decrease number of NK cells 94.5 [23; 136] to 32.5 [13; 90.8] (0.0625)]. Plasma levels of IL-6 464 [201-770] to 108 (89-140) ng/mL (p = 0.04) and IL-10 from IL-10 from 29 [12-59] to 9 [1-15] pg/mL decreased significantly. Three patients who received IFNγ early after ICU admission (\textless4 days) died. The other patients had a rapid clinical improvement assessed by the SOFA score and bacterial cultures that were repeatedly positive became negative. The 2 pediatric cases improved rapidly, but 1 died for hemorrhagic complication. CONCLUSION: Guided by clinical and immunological monitoring, adjunctive immunotherapy with ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/31690258; hal-02359951; https://hal.science/hal-02359951Test; https://hal.science/hal-02359951/documentTest; https://hal.science/hal-02359951/file/s12879-019-4526-x.pdfTest; PUBMED: 31690258; PUBMEDCENTRAL: PMC6833157 |
| DOI: | 10.1186/s12879-019-4526-x |
| الإتاحة: | https://doi.org/10.1186/s12879-019-4526-xTest https://hal.science/hal-02359951Test https://hal.science/hal-02359951/documentTest https://hal.science/hal-02359951/file/s12879-019-4526-x.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.6BB7B331 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12879-019-4526-x |
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