دورية أكاديمية
Allele Polymorphism and Haplotype Diversity of HLA-A, -B and -DRB1 Loci in Sequence-Based Typing for Chinese Uyghur Ethnic Group
| العنوان: | Allele Polymorphism and Haplotype Diversity of HLA-A, -B and -DRB1 Loci in Sequence-Based Typing for Chinese Uyghur Ethnic Group |
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| المؤلفون: | Deng, Ya-jun, Ye, Shi-hui, Yan, Jiang-wei, Yang, Guang, Wang, Hong-dan, Qin, Hai-xia, Huang, Qi-zhao, Zhang, Jing-Jing, Shen, Chun-mei, Zhu, Bo-feng |
| المساهمون: | Vascular Biology Center, Institute of Molecular Medicine and Genetics |
| سنة النشر: | 2010 |
| المجموعة: | Augusta University: Scholarly Commons |
| مصطلحات موضوعية: | Research Article, Genetics and Genomics/Population Genetics, Immunology/Genetics of the Immune System, Evolutionary Biology/Human Evolution, Alleles, Asian Continental Ancestry Group, China, Gene Frequency, Genetic Variation, Genotype, HLA-A Antigens, HLA-B Antigens, HLA-DR Antigens, HLA-DRB1 Chains, Haplotypes, Humans, Linkage Disequilibrium, Phylogeny, Polymorphism, Genetic |
| الوصف: | Background: Previous studies indicate that the frequency distributions of HLA alleles and haplotypes vary from one ethnic group to another or between the members of the same ethnic group living in different geographic areas. It is necessary and meaningful to study the high-resolution allelic and haplotypic distributions of HLA loci in different groups. ; Methodology/Principal Findings: High-resolution HLA typing for the Uyghur ethnic minority group using polymerase chain reaction-sequence-based-typing method was first reported. HLA-A, -B and -DRB1 allelic distributions were determined in 104 unrelated healthy Uyghur individuals and haplotypic frequencies and linkage disequilibrium parameters for HLA loci were estimated using the maximum-likelihood method. A total of 35 HLA-A, 51 HLA-B and 33 HLA-DRB1 alleles were identified at the four-digit level in the population. High frequency alleles were HLA-A*1101 (13.46%), A*0201 (12.50%), A*0301 (10.10%); HLA-B*5101(8.17%), B*3501(6.73%), B*5001 (6.25%); HLA-DRB1*0701 (16.35%), DRB1*1501 (8.65%) and DRB1*0301 (7.69%). The two-locus haplotypes at the highest frequency were HLA-A*3001-B*1302 (2.88%), A*2402-B*5101 (2.86%); HLA-B*5001-DRB1*0701 (4.14%) and B*0702-DRB1*1501 (3.37%). The three-locus haplotype at the highest frequency was HLA-A*3001-B*1302-DRB1*0701(2.40%). Significantly high linkage disequilibrium was observed in six two-locus haplotypes, with their corresponding relative linkage disequilibrium parameters equal to 1. Neighbor-joining phylogenetic tree between the Uyghur group and other previously reported populations was constructed on the basis of standard genetic distances among the populations calculated using the four-digit sequence-level allelic frequencies at HLA-A, HLA-B and HLA-DRB1 loci. The phylogenetic analyses reveal that the Uyghur group belongs to the northwestern Chinese populations and is most closely related to the Xibe group, and then to Kirgiz, Hui, Mongolian and Northern Han. ; Conclusions/Significance: The present findings could be ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 1932-6203 |
| العلاقة: | PLoS One. 2010 Nov 4; 5(11):e13458; http://hdl.handle.net/10675.2/607Test; PMC2973946 |
| DOI: | 10.1371/journal.pone.0013458 |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0013458Test http://hdl.handle.net/10675.2/607Test |
| حقوق: | Shen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| رقم الانضمام: | edsbas.6BB03DA4 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0013458 |