التفاصيل البيبلوغرافية
| العنوان: |
Improving B0 Correction for pH-Weighted Amine Proton Chemical Exchange Saturation Transfer (CEST) Imaging by Use of k-Means Clustering and Lorentzian Estimation |
| المؤلفون: |
Jingwen Yao, Dan Ruan, Catalina Raymond, Linda M. Liau, Noriko Salamon, Whitney B. Pope, Phioanh L. Nghiemphu, Albert Lai, Timothy F. Cloughesy, Benjamin M. Ellingson |
| المصدر: |
Tomography; Volume 4; Issue 3; Pages: 123-137 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2018 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
chemical exchange saturation transfer, B 0 correction, amine CEST EPI, pH-weighted MRI |
| الوصف: |
Amine chemical exchange saturation transfer (CEST) echoplanar imaging (EPI) provides unique pH and amino acid MRI contrast, enabling sensitive detection of altered microenvironment properties in various diseases. However, CEST contrast is sensitive to static magnetic field (B0) inhomogeneities. Here we propose 2 new B0 correction algorithms for use in correcting pH-weighted amine CEST EPI based on k-means clustering and Lorentzian fitting of CEST data: the iterative downsampling estimation using Lorentzian fitting and the 2-stage Lorentzian estimation with 4D polynomial fitting. Higher quality images of asymmetric magnetization transfer ratio (MTRasym) at 3.0 ppm could be obtained with the proposed algorithms than with the existing B0 correction methods. In particular, the proposed methods are shown to improve the intertissue consistency, interpatient consistency, and tumor region signal-to-noise ratio of MTRasym at 3.0 ppm images, with nonexcessive computation time. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
https://dx.doi.org/10.18383/j.tom.2018.00017Test |
| DOI: |
10.18383/j.tom.2018.00017 |
| الإتاحة: |
https://doi.org/10.18383/j.tom.2018.00017Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.6B7029F1 |
| قاعدة البيانات: |
BASE |
