دورية أكاديمية
Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence
| العنوان: | Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence |
|---|---|
| المؤلفون: | Choudhary, P., Monasso, G., Karhunen, V., Ronkainen, J., Mancano, G., Howe, C., Niu, Z., Zeng, X., Guan, W., Dou, J., Feinberg, J., Mordaunt, C., Pesce, G., Baiz, N., Alfano, R., Martens, D., Wang, C., Isaevska, E., Keikkala, E., Mustaniemi, S., Thio, C., Fraszczyk, E., Tobi, E., Starling, A., Cosin-Tomas, M., Urquiza, J., Roeder, S., Hoang, T., Page, C., Jima, D., House, J., Maguire, R., Ott, R., Pawlow, X., Sirignano, L., Zillich, L., Malmberg, A., Rauschert, S., Melton, P., Gong, T., Karlsson, R., Fore, R., Perng, W., Laubach, Z., Czamara, D., Sharp, G., Breton, C., Schisterman, E., Yeung, E., Mumford, S., Fallin, M., Lasalle, J., Schmidt, R., Bakulski, K., Annesi-Maesano, I., Heude, B., Nawrot, T., Plusquin, M., Ghantous, A., Herceg, Z., Nistico, L., Vafeiadi, M., Kogevinas, M., Vaeaeraesmaeki, M., Kajantie, E., Snieder, H., Corpeleijn, E., Steegers-Theunissen, R., Yang, I., Dabelea, D., Fossati, S., Zenclussen, A., Herberth, G., Magnus, M., Haberg, S., London, S., Munthe-Kaas, M., Murphy, S., Hoyo, C., Ziegler, A., Hummel, S., Witt, S., Streit, F., Frank, J., Raeikkoenen, K., Lahti, J., Huang, R., Almqvist, C., Hivert, M., Jaddoe, V., Jaervelin, M., Kantomaa, M., Felix, J., Sebert, S. |
| المصدر: | MOLECULAR PSYCHIATRY |
| سنة النشر: | 2023 |
| المجموعة: | Max Planck Society: MPG.PuRe |
| الوصف: | Maternal educational attainment (MEA) shapes offspring health through multiple potential pathways. Differential DNA methylation may provide a mechanistic understanding of these long-term associations. We aimed to quantify the associations of MEA with offspring DNA methylation levels at birth, in childhood and in adolescence. Using 37 studies from high-income countries, we performed meta-analysis of epigenome-wide association studies (EWAS) to quantify the associations of completed years of MEA at the time of pregnancy with offspring DNA methylation levels at birth (n = 9 881), in childhood (n = 2 017), and adolescence (n = 2 740), adjusting for relevant covariates. MEA was found to be associated with DNA methylation at 473 cytosine-phosphate-guanine sites at birth, one in childhood, and four in adolescence. We observed enrichment for findings from previous EWAS on maternal folate, vitamin-B12 concentrations, maternal smoking, and pre-pregnancy BMI. The associations were directionally consistent with MEA being inversely associated with behaviours including smoking and BMI. Our findings form a bridge between socio-economic factors and biology and highlight potential pathways underlying effects of maternal education. The results broaden our understanding of bio-social associations linked to differential DNA methylation in multiple early stages of life. The data generated also offers an important resource to help a more precise understanding of the social determinants of health. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | http://hdl.handle.net/21.11116/0000-000E-3F64-CTest |
| الإتاحة: | https://doi.org/10.1038/s41380-023-02331-5Test http://hdl.handle.net/21.11116/0000-000E-3F64-CTest |
| رقم الانضمام: | edsbas.6B55E6CB |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |