دورية أكاديمية
Protective Effect of Nopal Cactus (Opuntia ficus-indica) Seed Oil against Short-Term Lipopolysaccharides-Induced Inflammation and Peroxisomal Functions Dysregulation in Mouse Brain and Liver
| العنوان: | Protective Effect of Nopal Cactus (Opuntia ficus-indica) Seed Oil against Short-Term Lipopolysaccharides-Induced Inflammation and Peroxisomal Functions Dysregulation in Mouse Brain and Liver |
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| المؤلفون: | Tahri-Joutey, Mounia, Saih, Fatima-Ezzahra, El Kebbaj, Riad, Gondcaille, Catherine, Vamecq, Joseph, Latruffe, Norbert, Lizard, Gérard, Savary, Stéphane, Nasser, Boubker, Cherkaoui-Malki, Mustapha, Andreoletti, Pierre |
| المساهمون: | Laboratoire Bio-PeroxIL. Biochimie du peroxysome, inflammation et métabolisme lipidique Dijon (BIO-PEROXIL), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Bourgogne Franche-Comté COMUE (UBFC), Faculty of Science and Technology, University Hassan I, Laboratoire Bio-PeroxIL. Biochimie du Peroxysome, Inflammation et Métabolisme Lipidique (Bio-PeroxIL), Université de Bourgogne (UB), Laboratoire de Biochimie, Faculté des Sciences et Techniques Settat (FSTS), Université Hassan 1er Settat -Université Hassan 1er Settat, Université Hassan 1er Settat, Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Laboratoire d'Hormonologie, Métabolisme-Nutrition & Oncologie (HMNO), Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille)-Département de Biochimie et Biologie Moléculaire-Centre de Biologie et Pathologie (CBP) Pierre-Marie Degand-INSERM Structures Partenaires, Maladies RAres du DEveloppement embryonnaire et du MEtabolisme : du Phénotype au Génotype et à la Fonction - ULR 7364 (RADEME), Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Laboratoire de Biochimie Moléculaire et Cellulaire (LBMC), Laboratoire de Biochimie et Neurosciences Settat, Maroc, Lipides - Nutrition - Cancer (U866) (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA) |
| المصدر: | ISSN: 1661-6596. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2022 |
| المجموعة: | LillOA (HAL Lille Open Archive, Université de Lille) |
| مصطلحات موضوعية: | ACOX1, GPx, Il-1β, Il-6, SOD1, cactus seed oil, catalase, iNos, lipopolysaccharides, peroxisome, MESH: Animals, MESH: Antioxidants, MESH: Liver, MESH: Mice, MESH: Olive Oil, MESH: Opuntia, MESH: Brain, MESH: Catalase, MESH: Glutathione Peroxidase, MESH: Inflammation, MESH: Interleukin-6, MESH: Lipopolysaccharides, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism |
| الوصف: | Exposure to endotoxins (lipopolysaccharides, LPS) may lead to a potent inflammatory cytokine response and a severe impairment of metabolism, causing tissue injury. The protective effect provided by cactus seed oil (CSO), from Opuntia ficus-indica, was evaluated against LPS-induced inflammation, dysregulation of peroxisomal antioxidant, and β-oxidation activities in the brain and the liver. In both tissues, a short-term LPS exposure increased the proinflammatory interleukine-1β (Il-1β), inducible Nitroxide synthase (iNos), and Interleukine-6 (Il-6). In the brain, CSO action reduced only LPS-induced iNos expression, while in the liver, CSO attenuated mainly the hepatic Il-1β and Il-6. Regarding the peroxisomal antioxidative functions, CSO treatment (as Olive oil (OO) or Colza oil (CO) treatment) induced the hepatic peroxisomal Cat gene. Paradoxically, we showed that CSO, as well as OO or CO, treatment can timely induce catalase activity or prevent its induction by LPS, respectively, in both brain and liver tissues. On the other hand, CSO (as CO) pretreatment prevented the LPS-associated Acox1 gene and activity decreases in the liver. Collectively, CSO showed efficient neuroprotective and hepato-protective effects against LPS, by maintaining the brain peroxisomal antioxidant enzyme activities of catalase and glutathione peroxidase, and by restoring hepatic peroxisomal antioxidant and β-oxidative capacities. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/36233157; hal-04342093; https://u-bourgogne.hal.science/hal-04342093Test; https://u-bourgogne.hal.science/hal-04342093/documentTest; https://u-bourgogne.hal.science/hal-04342093/file/ijms-23-11849.pdfTest; PUBMED: 36233157; PUBMEDCENTRAL: PMC9569537 |
| DOI: | 10.3390/ijms231911849 |
| الإتاحة: | https://doi.org/10.3390/ijms231911849Test https://u-bourgogne.hal.science/hal-04342093Test https://u-bourgogne.hal.science/hal-04342093/documentTest https://u-bourgogne.hal.science/hal-04342093/file/ijms-23-11849.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.6A94C19C |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms231911849 |
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