دورية أكاديمية
Childhood cancer and residential proximity to petrol stations: a nationwide registry-based case-control study in Switzerland and an updated meta-analysis.
| العنوان: | Childhood cancer and residential proximity to petrol stations: a nationwide registry-based case-control study in Switzerland and an updated meta-analysis. |
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| المؤلفون: | Mazzei, A., Konstantinoudis, G., Kreis, C., Diezi, M., Ammann, R.A., Zwahlen, M., Kühni, C., Spycher, B.D. |
| المصدر: | International archives of occupational and environmental health, vol. 95, no. 5, pp. 927-938 |
| سنة النشر: | 2022 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | Adolescent, Air Pollutants/analysis, Benzene/analysis, Case-Control Studies, Child, Preschool, Environmental Exposure/adverse effects, Environmental Exposure/analysis, Humans, Infant, Newborn, Leukemia/chemically induced, Leukemia/epidemiology, Neoplasms/chemically induced, Neoplasms/epidemiology, Registries, Switzerland/epidemiology, Air pollution, Benzene, Hematological cancer, Solvents |
| الوصف: | Benzene is a known carcinogen for adult leukemia. Exposure to benzene through parental occupation and the use of household products has been associated with childhood leukemia (CL). Ambient benzene has also been associated with CL and central nervous system (CNS) tumors. We aimed to investigate whether the higher ambient levels of benzene in proximity of petrol stations are associated with a greater risk of childhood cancers, leukemia, and CNS tumors. We identified children diagnosed with cancer at age 0-15 years during 1985-2015 from the Swiss Childhood Cancer Registry and selected 10 age and sex-matched controls per case from national censuses. We calculated the distance from children's home to the nearest petrol station using precise geocodes. We estimated odds ratios using conditional logistic regression adjusting for ambient levels of NO 2 , distance to highways, level of urbanization, and presence of a cantonal cancer registry. In addition, we ran a meta-analysis pooling current results for CL with those of previous studies. We identified 6129 cases, of which 1880 were leukemias and 1290 CNS tumors. 24 cases lived within 50 m from a petrol station. The adjusted odds ratio of a cancer diagnosis for children thus exposed compared to unexposed children (> 500 m) was 1.29 (0.84-1.98) for all cancers combined, 1.08 (0.46-2.51) for leukemia, and 1.30 (0.51-3.35) for CNS tumors. During 2000-2015, when exposure assessment was more precise, the adjusted odds ratio for any cancer diagnosis was 1.77 (1.05-2.98). The summary relative risk estimate for CL in the meta-analysis including four studies was 2.01 (1.25-3.22). Our study provides weak support for an increased risk of childhood cancers among children living close to petrol stations. A meta-analysis including our study suggests an increased risk for CL. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0340-0131 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34652533; info:eu-repo/semantics/altIdentifier/eissn/1432-1246; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_AAA605FA4E749; https://serval.unil.ch/notice/serval:BIB_AAA605FA4E74Test; urn:issn:0340-0131; https://serval.unil.ch/resource/serval:BIB_AAA605FA4E74.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_AAA605FA4E749Test |
| DOI: | 10.1007/s00420-021-01767-y |
| الإتاحة: | https://doi.org/10.1007/s00420-021-01767-yTest https://serval.unil.ch/notice/serval:BIB_AAA605FA4E74Test https://serval.unil.ch/resource/serval:BIB_AAA605FA4E74.P001/REF.pdfTest http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_AAA605FA4E749Test |
| حقوق: | info:eu-repo/semantics/openAccess ; CC BY 4.0 ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.6A7D0D18 |
| قاعدة البيانات: | BASE |
| تدمد: | 03400131 |
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| DOI: | 10.1007/s00420-021-01767-y |