دورية أكاديمية
Multicenter validation of the CamGFR model for estimated glomerular filtration rate
| العنوان: | Multicenter validation of the CamGFR model for estimated glomerular filtration rate |
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| المؤلفون: | Williams, Edward H., Connell, Claire M., Weaver, James M. J., Beh, Ian, Potts, Harry, Whitley, Cameron T., Bird, Nicholas, Al-Sayed, Tamer, Fehr, Martin, Cathomas, Richard, Bertelli, Gianfilippo, Quinton, Amy, Lewis, Paul, Shamash, Jonathan, Wilson, Peter, Dooley, Michael, Poole, Susan, Mark, Patrick B., Bookman, Michael, Earl, Helena, Jodrell, Duncan, Tavaré, Simon, Lynch, Andy, Janowitz, Tobias |
| المساهمون: | University of St Andrews. Statistics, University of St Andrews. Sir James Mackenzie Institute for Early Diagnosis, University of St Andrews. Cellular Medicine Division, University of St Andrews. School of Medicine |
| سنة النشر: | 2020 |
| المجموعة: | University of St Andrews: Digital Research Repository |
| مصطلحات موضوعية: | RC0254 Neoplasms. Tumors. Oncology (including Cancer), 3rd-DAS, SDG 3 - Good Health and Well-being, RC0254 |
| الوصف: | This work was supported by Cancer Research UK (EHW, TJ: C42738/A24868); National Institute of Health Research Cambridge Biomedical Research Centre (HE); National Institute of Health Research UK Academic Clinical Fellowship (CMC); and National Institutes of Health USA Cancer Center support grant (TJ: 5P30CA045508-31). ; Important oncological management decisions rely on kidney function assessed by serum creatinine-based estimated glomerular filtration rate (eGFR). However, no large-scale multicentre comparison of methods to determine eGFR in patients with cancer are available. To compare the performance of formulas for eGFR based on routine clinical parameters and serum creatinine not calibrated with isotope dilution mass spectrometry (non-IDMS), we studied 3,620 patients with cancer and 166 without cancer who had their GFR measured with an exogenous nuclear tracer at one of seven clinical centres. The mean measured GFR was 86 ml/min. Accuracy of all models was centre-dependent, reflecting inter-centre variability of non-IDMS creatinine measurements. CamGFR was the most accurate model for eGFR (root-mean-squared-error (RMSE) 17.3 ml/min) followed by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) model (RMSE 18.2 ml/min).Important oncological management decisions rely on kidney function assessed by serum creatinine-based estimated glomerular filtration rate (eGFR). However, no large-scale multicentre comparison of methods to determine eGFR in patients with cancer are available. To compare the performance of formulas for eGFR based on routine clinical parameters and serum creatinine not calibrated with isotope dilution mass spectrometry (non-IDMS), we studied 3,620 patients with cancer and 166 without cancer who had their GFR measured with an exogenous nuclear tracer at one of seven clinical centres. The mean measured GFR was 86 ml/min. Accuracy of all models was centre-dependent, reflecting inter-centre variability of non-IDMS creatinine measurements. CamGFR was the most accurate model for eGFR ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| ردمك: | 978-0-00-503271-8 0-00-503271-7 |
| تدمد: | 2515-5091 |
| العلاقة: | JNCI Cancer Spectrum; Williams , E H , Connell , C M , Weaver , J M J , Beh , I , Potts , H , Whitley , C T , Bird , N , Al-Sayed , T , Fehr , M , Cathomas , R , Bertelli , G , Quinton , A , Lewis , P , Shamash , J , Wilson , P , Dooley , M , Poole , S , Mark , P B , Bookman , M , Earl , H , Jodrell , D , Tavaré , S , Lynch , A & Janowitz , T 2019 , ' Multicenter validation of the CamGFR model for estimated glomerular filtration rate ' , JNCI Cancer Spectrum , vol. 3 , no. 4 , pkz068 . https://doi.org/10.1093/jncics/pkz068Test; PURE: 259452795; PURE UUID: 99175122-e0c8-4672-9cfc-8149b6eabce2; ORCID: /0000-0002-7876-7338/work/63381025; WOS: 000503271700015; Scopus: 85087185771; http://hdl.handle.net/10023/19221Test; https://doi.org/10.1093/jncics/pkz068Test |
| DOI: | 10.1093/jncics/pkz068 |
| الإتاحة: | https://doi.org/10.1093/jncics/pkz068Test http://hdl.handle.net/10023/19221Test |
| حقوق: | Copyright © The Author(s) 2019. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0Test/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| رقم الانضمام: | edsbas.6A3C0681 |
| قاعدة البيانات: | BASE |
Full Text Finder | ردمك: | 9780005032718 0005032717 |
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| تدمد: | 25155091 |
| DOI: | 10.1093/jncics/pkz068 |