دورية أكاديمية
Creatinine- versus cystatine C-based equations in assessing the renal function of candidates for liver transplantation with cirrhosis
| العنوان: | Creatinine- versus cystatine C-based equations in assessing the renal function of candidates for liver transplantation with cirrhosis |
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| المؤلفون: | de Souza, V., Hadj-Aissa, A., Dolomanova, O., Rabilloud, Muriel, Rognant, N., Lemoine, Sandrine, Radenne, S., Dumortier, J., Chapuis-Cellier, C., Beyerle, F., Bon, C., Iwaz, J., Selistre, L., Dubourg, L. |
| المساهمون: | Biostatistiques santé, Département biostatistiques et modélisation pour la santé et l'environnement LBBE, Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | ISSN: 0270-9139. |
| بيانات النشر: | HAL CCSD Wiley-Blackwell |
| سنة النشر: | 2014 |
| المجموعة: | HAL Lyon 1 (University Claude Bernard Lyon 1) |
| مصطلحات موضوعية: | Adolescent, Adult, Female, Humans, Male, Biomarkers/blood, Predictive Value of Tests, Aged, Middle Aged, Young Adult, Severity of Illness Index, Liver Transplantation, Models, Biological, Glomerular Filtration Rate/*physiology, Cystatin C/*blood, Creatinine/*blood, Inulin/metabolism, Kidney/*physiology, Liver Cirrhosis/blood/*surgery, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Renal dysfunction is frequent in liver cirrhosis and is a strong prognostic predictor of orthotopic liver transplantation (OLT) outcome. Therefore, an accurate evaluation of the glomerular filtration rate (GFR) is crucial in pre-OLT patients. However, in these patients plasma creatinine (Pcr) is inaccurate and the place of serum cystatine C (CystC) is still debated. New GFR-predicting equations, based on standardized assays of Pcr and/or CystC, have been recently recommended in the general population but their performance in cirrhosis patients has been rarely studied. We evaluated the performance of the recently published Chronic Kidney Disease Epidemiology Collaboration equations (CKD-EPI-Pcr, CKD-EPI-CystC, and CKD-EPI-Pcr-CystC) and the more classical ones (4- and 6-variable MDRD and Hoek formulas) in cirrhosis patients referred for renal evaluation before OLT. Inulin clearance was performed in 202 consecutive patients together with the determination of Pcr and CystC with assays traceable to primary reference materials. The performance of the GFR-predicting equations was evaluated according to ascites severity (no, moderate, or refractory) and to hepatic and renal dysfunctions (MELD score \textless/= or \textgreater15 and KDOQI stages, respectively). In the whole population, CystC-based equations showed a better performance than Pcr-based ones (lower bias and higher 10% and 30% accuracies). CKD-EPI-CystC equation showed the best performance whatever the ascites severity and in presence of a significant renal dysfunction (GFR \textless60 mL/min/1.73 m(2)). CONCLUSION: Pcr-based GFR predicting equations are not reliable in pre-OLT patients even when an IDMS-traceable enzymatic Pcr assay is used. Whenever a CystC-assay traceable to primary reference materials is performed and when a true measurement of GFR is not possible, CystC-based equations, especially CKD-EPI-CystC, may be recommended to evaluate renal function and for KDOQI staging. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-01859023; https://hal.science/hal-01859023Test |
| DOI: | 10.1002/hep.26886 |
| الإتاحة: | https://doi.org/10.1002/hep.26886Test https://hal.science/hal-01859023Test |
| رقم الانضمام: | edsbas.6A2C9FD4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/hep.26886 |
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