دورية أكاديمية
Association between Childhood Overweight and Altered Concentrations of Circulating Amino Acids.
| العنوان: | Association between Childhood Overweight and Altered Concentrations of Circulating Amino Acids. |
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| المؤلفون: | Campos, Jéssica de Oliveira, Oliveira, Tafnes Laís Pereira Santos de Almeida, Vitalis, Oriane, Pereira, Jéssica Gonzaga, Nogueira, Isabella da Costa Ribeiro, Santos, Gabriela Carvalho Jurema, Chikh, Karim, Leandro, Carol Gois, Costa-Silva, João Henrique da, Pirola, Luciano |
| المصدر: | Nutrients ; ISSN:2072-6643 ; Volume:16 ; Issue:12 |
| بيانات النشر: | MDPI |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | amino acids, branched chain amino acids (BCAA), childhood overweight, glycine, metabolomics |
| الوصف: | (1) Background: Dysregulated serum amino acids (AA) are known to be associated with obesity and risk of Type 2 Diabetes (T2D) in adults, and recent studies support the same notion in the pubertal age. It is, however, unknown whether childhood overweight may already display alterations of circulating AA. (2) Methods: We used liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS)-targeted metabolomics to determine plasma concentrations of AA and AA-related molecules in 36 children aged 7-12 years with normal weight or overweight. Clinical and anthropometric parameters were measured. (3) Results: Overweight in children is associated with an altered AA profile, with increased branched-chain amino acids (BCAA) and decreased glycine levels, with no clinically manifested metabolic conditions. Moreover, z-BMI was positively and negatively correlated with BCAA and glycine levels, respectively, even after adjustment for age and gender. We also found a correlation between the AA profile and clinical parameters such as lipids profile and glycemia. (4) Conclusions: A pattern of low glycine, and increased BCAA is correlated to z-BMI, total cholesterol, and triglycerides in overweight but otherwise healthy children. Our data suggest that, in childhood overweight, AA disturbances may precede other clinical parameters, thus providing an early indicator for the later development of metabolic disease. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.3390/nu16121843Test; https://pubmed.ncbi.nlm.nih.gov/38931197Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11206240Test/ |
| DOI: | 10.3390/nu16121843 |
| الإتاحة: | https://doi.org/10.3390/nu16121843Test https://pubmed.ncbi.nlm.nih.gov/38931197Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11206240Test/ |
| رقم الانضمام: | edsbas.6A062C20 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/nu16121843 |
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