دورية أكاديمية
Role of dipeptidyl peptidase-4 (DPP4) on COVID-19 physiopathology
| العنوان: | Role of dipeptidyl peptidase-4 (DPP4) on COVID-19 physiopathology |
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| المؤلفون: | Sebastián Martín, Alba, Sánchez Gómez, Belén, Mora Rodríguez, José María, Bort Bueno, Alicia Carmen, Díaz-Laviada Marturet, Inés Cecilia |
| المساهمون: | Universidad de Alcalá. Departamento de Biología de Sistemas |
| سنة النشر: | 2022 |
| المجموعة: | e_Buah - Biblioteca Digital de la Universidad de Alcalá |
| مصطلحات موضوعية: | DPP4, CD26, type 2 diabetes, inflammation, SARS-CoV-2, COVID-19, gliptins, Medicina, Medicine |
| الوصف: | DPP4/CD26 is a single-pass transmembrane protein with multiple functions on glycemic control, cell migration and proliferation, and the immune system, among others. It has recently acquired an especial relevance due to the possibility to act as a receptor or co-receptor for SARS-CoV-2, as it has been already demonstrated for other coronaviruses. In this review, we analyze the evidence for the role of DPP4 on COVID-19 risk and clinical outcome, and its contribution to COVID-19 physiopathology. Due to the pathogenetic links between COVID-19 and diabetes mellitus and the hyperinflammatory response, with the hallmark cytokine storm developed very often during the disease, we dive deep into the functions of DPP4 on carbohydrate metabolism and immune system regulation. We show that the broad spectrum of functions regulated by DPP4 is performed both as a protease enzyme, as well as an interacting partner of other molecules on the cell surface. In addition, we provide an update of the DPP4 inhibitors approved by the EMA and/or the FDA, together with the newfangled approval of generic drugs (in 2021 and 2022). This review will also cover the effects of DPP4 inhibitors (i.e., gliptins) on the progression of SARS-CoV-2 infection, showing the role of DPP4 in this disturbing disease. ; Comunidad Autónoma de Madrid ; Instituto de Salud Carlos III ; Fundación Tatiana Pérez de Guzmán el Bueno ; Ministerio de Educación, Cultura y Deporte |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2227-9059 |
| العلاقة: | info:eu-repo/grantAgreement/CAM//REACTUE-CM2021-02/ES//; info:eu-repo/grantAgreement/ISCIII//PI20%2F01327/ES//; info:eu-repo/grantAgreement/FT//2019-001/ES//; info:eu-repo/grantAgreement/UAH//CCG20%2FCC-011/ES//; info:eu-repo/grantAgreement/MECD/Programa Estatal de Promoción del Talento y su Empleabilidad en I+D+i/FPU17%2F03380/ES//; Biomedicines, 2022, v. 10, n. 8 (2026), p. 1-21; http://hdl.handle.net/10017/60461Test; AR/0000042489; Biomedicines; 10; 21; 8 (2026) |
| DOI: | 10.3390/biomedicines10082026 |
| الإتاحة: | https://doi.org/10.3390/biomedicines10082026Test http://hdl.handle.net/10017/60461Test |
| حقوق: | © 2022 by the authors ; Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.69F61556 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 22279059 |
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| DOI: | 10.3390/biomedicines10082026 |