التفاصيل البيبلوغرافية
| العنوان: |
Image_2_Human DC3 Antigen Presenting Dendritic Cells From Induced Pluripotent Stem Cells.TIFF |
| المؤلفون: |
Taiki Satoh (11170092), Marcelo A. S. Toledo (11170095), Janik Boehnke (11170098), Kathrin Olschok (11170101), Niclas Flosdorf (11170104), Katrin Götz (8949746), Caroline Küstermann (11170107), Stephanie Sontag (416324), Kristin Seré (9992297), Steffen Koschmieder (106779), Tim H. Brümmendorf (9263733), Nicolas Chatain (727303), Yoh-ichi Tagawa (11170110), Martin Zenke (162192) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Cell Biology, Marine Biology, Cell Development, Proliferation and Death, Cell Metabolism, Cell Neurochemistry, Cellular Interactions (incl. Adhesion, Matrix, Cell Wall), induced pluripotent stem cell, iPS cells, hematopoiesis, dendritic cells, DC3, JAK2, JAK2 V617F |
| الوصف: |
Dendritic cells (DC) are professional antigen-presenting cells that develop from hematopoietic stem cells. Different DC subsets exist based on ontogeny, location and function, including the recently identified proinflammatory DC3 subset. DC3 have the prominent activity to polarize CD8 + T cells into CD8 + CD103 + tissue resident T cells. Here we describe human DC3 differentiated from induced pluripotent stem cells (iPS cells). iPS cell-derived DC3 have the gene expression and surface marker make-up of blood DC3 and polarize CD8 + T cells into CD8 + CD103 + tissue-resident memory T cells in vitro. To test the impact of malignant JAK2 V617F mutation on DC3, we differentiated patient-specific iPS cells with JAK2 V617F het and JAK2 V617F hom mutations into JAK2 V617F het and JAK2 V617F hom DC3. The JAK2 V617F mutation enhanced DC3 production and caused a bias toward erythrocytes and megakaryocytes. The patient-specific iPS cell-derived DC3 are expected to allow studying DC3 in human diseases and developing novel therapeutics. |
| نوع الوثيقة: |
still image |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/figure/Image_2_Human_DC3_Antigen_Presenting_Dendritic_Cells_From_Induced_Pluripotent_Stem_Cells_TIFF/15034320Test |
| DOI: |
10.3389/fcell.2021.667304.s002 |
| الإتاحة: |
https://doi.org/10.3389/fcell.2021.667304.s002Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.69A9CBD |
| قاعدة البيانات: |
BASE |
