التفاصيل البيبلوغرافية
| العنوان: |
The important roles of miR-205 in normal physiology, cancers and as a potential therapeutic target |
| المؤلفون: |
Vosgha, Haleh, Salajegheh, Ali, Smith, Robert Anthony, Lam, Alfred King-Yin |
| بيانات النشر: |
Bentham Science |
| سنة النشر: |
2014 |
| المجموعة: |
Griffith University: Griffith Research Online |
| مصطلحات موضوعية: |
Medicinal and biomolecular chemistry, Oncology and carcinogenesis, Pharmacology and pharmaceutical sciences |
| الوصف: |
Evidences have demonstrated key mediatory roles of microRNA-205 (miR-205) in normal physiology and its aberrant expression in many cancers. Indeed, miR-205 has been identified as both a tumour suppressive and oncogenic miRNA playing crucial roles in tumourigenesis through regulating different cellular pathways such as cell survival, apoptosis, angiogenesis and metastasis. As a tumour suppressor, miR-205 acts as an inhibitor of cell proliferation, migration and invasion. On the other hand, as an oncogene, miR-205 promotes tumour initiation and development. All these functions act through different target genes in various types of cancers. Also, miR-205 displays potential as a therapeutic target for different cancers. To conclude, miR-205 has important clinical and pathological correlations in different cancers and may act as a diagnostic and prognostic marker as well as new molecular target for cancer therapy. ; Griffith Health, School of Medicine ; No Full Text |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| تدمد: |
1568-0096 |
| العلاقة: |
Current Cancer Drug Targets; http://www.ingentaconnect.com/content/ben/ccdt/2014/00000014/00000007/art00004Test; http://hdl.handle.net/10072/65570Test |
| الإتاحة: |
http://hdl.handle.net/10072/65570Test |
| رقم الانضمام: |
edsbas.6947972B |
| قاعدة البيانات: |
BASE |
