دورية أكاديمية
Circulating effector γδ T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals
| العنوان: | Circulating effector γδ T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals |
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| المؤلفون: | von Borstel, A, Nguyen, THO, Rowntree, LC, Ashhurst, TM, Allen, LF, Howson, LJ, Holmes, NE, Smibert, OC, Trubiano, JA, Gordon, CL, Cheng, AC, Kent, SJ, Rossjohn, J, Kedzierska, K, Davey, MS |
| بيانات النشر: | WILEY |
| سنة النشر: | 2023 |
| المجموعة: | The University of Melbourne: Digital Repository |
| الوصف: | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes severe coronavirus disease 2019 (COVID-19) in a small proportion of infected individuals. The immune system plays an important role in the defense against SARS-CoV-2, but our understanding of the cellular immune parameters that contribute to severe COVID-19 disease is incomplete. Here, we show that populations of effector γδ T cells are associated with COVID-19 in unvaccinated patients with acute disease. We found that circulating CD27neg CD45RA+ CX3CR1+ Vδ1effector cells expressing Granzymes (Gzms) were enriched in COVID-19 patients with acute disease. Moreover, higher frequencies of GzmB+ Vδ2+ T cells were observed in acute COVID-19 patients. SARS-CoV-2 infection did not alter the γδ T cell receptor repertoire of either Vδ1+ or Vδ2+ subsets. Our work demonstrates an association between effector populations of γδ T cells and acute COVID-19 in unvaccinated individuals. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0818-9641 1440-1711 |
| العلاقة: | NHMRC/1149990; NHMRC/1173871; NHMRC/1194036; NHMRC/2005544; NHMRC/2016062; von Borstel, A., Nguyen, T. H. O., Rowntree, L. C., Ashhurst, T. M., Allen, L. F., Howson, L. J., Holmes, N. E., Smibert, O. C., Trubiano, J. A., Gordon, C. L., Cheng, A. C., Kent, S. J., Rossjohn, J., Kedzierska, K. & Davey, M. S. (2023). Circulating effector γδ T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals. IMMUNOLOGY AND CELL BIOLOGY, 101 (4), pp.321-332. https://doi.org/10.1111/imcb.12623Test.; http://hdl.handle.net/11343/333407Test |
| الإتاحة: | https://doi.org/10.1111/imcb.12623Test http://hdl.handle.net/11343/333407Test |
| حقوق: | CC BY ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.69443CAD |
| قاعدة البيانات: | BASE |
| تدمد: | 08189641 14401711 |
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