دورية أكاديمية
Risk factors for melanoma by anatomical site: an evaluation of aetiological heterogeneity
| العنوان: | Risk factors for melanoma by anatomical site: an evaluation of aetiological heterogeneity |
|---|---|
| المؤلفون: | Laskar, R., Ferreiro-Iglesias, A., Bishop, D. T., Iles, Mark M., Kanetsky, P. A., Armstrong, B. K., Law, M. H., Goldstein, A. M., Aitken, J. F., Giles, Graham G., Robbins, H. A., Cust, Anne E., Mann, Graham J., Schmid, Helen, Hopper, John L., Holland, Elizabeth, Kefford, Richard F., Jenkins, Mark A., Newton Bishop, Julia A., Affleck, Paul, Barrett, Jennifer H., Harrison, Jane, Randerson-Moor, Juliette, Harland, Mark, Taylor, John C., Whittaker, Linda, Kukalizch, Kairen, Leake, Susan, Karpavicius, Birute, Haynes, Sue, Mack, Tricia, Chan, May, Taylor, Yvonne, Davies, John, King, Paul, other, and |
| المصدر: | British Journal of Dermatology |
| بيانات النشر: | Wiley-Blackwell Publishing Ltd |
| سنة النشر: | 2021 |
| المجموعة: | Queensland University of Technology: QUT ePrints |
| الوصف: | Background: Melanoma aetiology has been proposed to have two pathways, which are determined by naevi and type of sun exposure and related to the anatomical site where melanoma develops. Objectives: We examined associations with melanoma by anatomical site for a comprehensive set of risk factors including pigmentary and naevus phenotypes, ultraviolet radiation exposure and polygenic risk. Methods: We analysed harmonized data from 2617 people with incident first invasive melanoma and 975 healthy controls recruited through two population-based case–control studies in Australia and the UK. Questionnaire data were collected by interview using a single protocol, and pathway-specific polygenic risk scores were derived from DNA samples. We estimated adjusted odds ratios using unconditional logistic regression that compared melanoma cases at each anatomical site with all controls. Results: When cases were compared with control participants, there were stronger associations for many naevi vs. no naevi for melanomas on the trunk, and upper and lower limbs than on the head and neck (P-heterogeneity < 0·001). Very fair skin (vs. olive/brown skin) was more weakly related to melanoma on the trunk than to melanomas at other sites (P-heterogeneity = 0·04). There was no significant difference by anatomical site for polygenic risk. Increased weekday sun exposure was positively associated with melanoma on the head and neck but not on other sites. Conclusions: We found evidence of aetiological heterogeneity for melanoma, supporting the dual pathway hypothesis. These findings enhance understanding of risk factors for melanoma and can guide prevention and skin examination education and practices. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://eprints.qut.edu.au/229996/1/108712574.pdfTest; Laskar, R., Ferreiro-Iglesias, A., Bishop, D. T., Iles, Mark M., Kanetsky, P. A., Armstrong, B. K., Law, M. H., Goldstein, A. M., Aitken, J. F., Giles, Graham G., Robbins, H. A., Cust, Anne E., Mann, Graham J., Schmid, Helen, Hopper, John L., Holland, Elizabeth, Kefford, Richard F., Jenkins, Mark A., Newton Bishop, Julia A., Affleck, Paul, Barrett, Jennifer H., Harrison, Jane, Randerson-Moor, Juliette, Harland, Mark, Taylor, John C., Whittaker, Linda, Kukalizch, Kairen, Leake, Susan, Karpavicius, Birute, Haynes, Sue, Mack, Tricia, Chan, May, Taylor, Yvonne, Davies, John, King, Paul, & other, and (2021) Risk factors for melanoma by anatomical site: an evaluation of aetiological heterogeneity. British Journal of Dermatology, 184(6), pp. 1085-1093.; https://eprints.qut.edu.au/229996Test/; Faculty of Health; School of Biomedical Sciences |
| الإتاحة: | https://doi.org/10.1111/bjd.19705Test https://eprints.qut.edu.au/229996Test/ |
| حقوق: | free_to_read ; http://creativecommons.org/licenses/by/4.0Test/ ; 2020 The Author(s) ; This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au |
| رقم الانضمام: | edsbas.68E25AD3 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |