دورية أكاديمية
A computational framework to benchmark basket catheter guided ablation in atrial fibrillation
| العنوان: | A computational framework to benchmark basket catheter guided ablation in atrial fibrillation |
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| المؤلفون: | Alessandrini, Martino, Valinoti, Maddalena, Unger, Laura, Oesterlein, Tobias, Dössel, Olaf, Corsi, Cristiana, Loewe, Axel, Severi, Stefano |
| المساهمون: | Alessandrini, Martino, Valinoti, Maddalena, Unger, Laura, Oesterlein, Tobia, Dössel, Olaf, Corsi, Cristiana, Loewe, Axel*, Severi, Stefano |
| سنة النشر: | 2018 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | Ablation, Atrial fibrillation, Basket catheter, Computational modeling, Rotor, Physiology, Physiology (medical) |
| الوصف: | Catheter ablation is a curative therapeutic approach for atrial fibrillation (AF). Ablation of rotational sources based on basket catheter measurements has been proposed as a promising approach in patients with persistent AF to complement pulmonary vein isolation. However, clinically reported success rates are equivocal calling for a mechanistic investigation under controlled conditions. We present a computational framework to benchmark ablation strategies considering the whole cycle from excitation propagation to electrogram acquisition and processing to virtual therapy. Fibrillation was induced in a patient-specific 3D volumetric model of the left atrium, which was homogeneously remodeled to sustain reentry. The resulting extracellular potential field was sampled using models of grid catheters as well as realistically deformed basket catheters considering the specific atrial anatomy. The virtual electrograms were processed to compute phase singularity density maps to target rotor tips with up to three circular ablations. Stable rotors were successfully induced in different regions of the homogeneously remodeled atrium showing that rotors are not constrained to unique anatomical structures or locations. Density maps of rotor tip trajectories correctly identified and located the rotors (deviation < 10 mm) based on catheter recordings only for sufficient resolution (inter-electrode distance ≤3 mm) and proximity to the wall (≤10 mm). Targeting rotor sites with ablation did not stop reentries in the homogeneously remodeled atria independent from lesion size (1-7 mm radius), from linearly connecting lesions with anatomical obstacles, and from the number of rotors targeted sequentially (≤3). Our results show that phase maps derived from intracardiac electrograms can be a powerful tool to map atrial activation patterns, yet they can also be misleading due to inaccurate localization of the rotor tip depending on electrode resolution and distance to the wall. This should be considered to avoid ablating regions that ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/30298012; info:eu-repo/semantics/altIdentifier/wos/WOS:000445286000001; volume:9; issue:SEP; firstpage:1; lastpage:13; numberofpages:13; journal:FRONTIERS IN PHYSIOLOGY; info:eu-repo/grantAgreement/EC/H2020/659082; http://hdl.handle.net/11585/670881Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85055280238; http://www.frontiersin.org/Physiology/archiveTest/ |
| DOI: | 10.3389/fphys.2018.01251 |
| الإتاحة: | https://doi.org/10.3389/fphys.2018.01251Test http://hdl.handle.net/11585/670881Test http://www.frontiersin.org/Physiology/archiveTest/ |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.68B37887 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fphys.2018.01251 |
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