دورية أكاديمية
Clinical outcomes of a zika virus mother–child pair cohort in Spain
| العنوان: | Clinical outcomes of a zika virus mother–child pair cohort in Spain |
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| المؤلفون: | Soriano-Arandes A., Frick M. A., Lopez-Hortelano M. G., Sulleiro E., Rodo C., Sanchez-Seco M. P., Cabrera-Lafuente M., Suy A., De la Calle M., Santos M., Antolin E., Vinuela M. C., Espiau M., Salazar A., Guarch-Ibanez B., Vazquez A., Navarro-Moron J., Ramos-Amador J. -T., Martin-Nalda A., Duenas E., Blazquez-Gamero D., Reques-Cosme R., Olabarrieta I., Prieto L., De Ory F., Thorne C., Byrne T., Ades A. E., Ruiz-Burga E., Giaquinto C., Mellado-Pena M. J., Garcia-Alix A., Carreras E., Soler-Palacin P. |
| المساهمون: | Soriano-Arandes, A., Frick, M. A., Lopez-Hortelano, M. G., Sulleiro, E., Rodo, C., Sanchez-Seco, M. P., Cabrera-Lafuente, M., Suy, A., De la Calle, M., Santos, M., Antolin, E., Vinuela, M. C., Espiau, M., Salazar, A., Guarch-Ibanez, B., Vazquez, A., Navarro-Moron, J., Ramos-Amador, J. -T., Martin-Nalda, A., Duenas, E., Blazquez-Gamero, D., Reques-Cosme, R., Olabarrieta, I., Prieto, L., De Ory, F., Thorne, C., Byrne, T., Ades, A. E., Ruiz-Burga, E., Giaquinto, C., Mellado-Pena, M. J., Garcia-Alix, A., Carreras, E., Soler-Palacin, P. |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2020 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: | Adverse outcome, Arboviruse, Congenital infection, Microcephaly, Zika virus |
| الوصف: | Background: Zika virus (ZIKV) infection has been associated with congenital microcephaly and other neurodevelopmental abnormalities. There is little published research on the effect of maternal ZIKV infection in a non-endemic European region. We aimed to describe the outcomes of pregnant travelers diagnosed as ZIKV-infected in Spain, and their exposed children. Methods: This prospective observational cohort study of nine referral hospitals enrolled pregnant women (PW) who travelled to endemic areas during their pregnancy or the two previous months, or those whose sexual partners visited endemic areas in the previous 6 months. Infants of ZIKV-infected mothers were followed for about two years. Results: ZIKV infection was diagnosed in 163 PW; 112 (70%) were asymptomatic and 24 (14.7%) were confirmed cases. Among 143 infants, 14 (9.8%) had adverse outcomes during follow-up; three had a congenital Zika syndrome (CZS), and 11 other potential Zika-related outcomes. The overall incidence of CZS was 2.1% (95%CI: 0.4–6.0%), but among infants born to ZIKV-confirmed mothers, this increased to 15.8% (95%CI: 3.4–39.6%). Conclusions: A nearly 10% overall risk of neurologic and hearing adverse outcomes was found in ZIKV-exposed children born to a ZIKV-infected traveler PW. Longer-term follow-up of these children is needed to assess whether there are any later-onset manifestations. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/32392815; info:eu-repo/semantics/altIdentifier/wos/WOS:000541443700035; volume:9; issue:5; firstpage:352; journal:PATHOGENS; http://hdl.handle.net/11577/3353996Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85084485626 |
| DOI: | 10.3390/pathogens9050352 |
| الإتاحة: | https://doi.org/10.3390/pathogens9050352Test http://hdl.handle.net/11577/3353996Test |
| رقم الانضمام: | edsbas.68A2CE7C |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/pathogens9050352 |
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