التفاصيل البيبلوغرافية
| العنوان: |
Construction and validation of a risk prediction model for perianal infection in patients with haematological malignancies during chemotherapy: a prospective study in a tertiary hospital in China |
| المؤلفون: |
Wang, Yingli, Luo, Yuqin, Leng, Yamei, Yang, Mei, Liang, Taoyun, Niu, Ting |
| المساهمون: |
West China Hospital, Sichuan University, West China Nursing Discipline Development Special Fund Project, Sichuan University |
| المصدر: |
BMJ Open ; volume 13, issue 8, page e074196 ; ISSN 2044-6055 2044-6055 |
| بيانات النشر: |
BMJ |
| سنة النشر: |
2023 |
| مصطلحات موضوعية: |
General Medicine |
| الوصف: |
Objectives Perianal infection is a serious complication in patients undergoing chemotherapy for haematological malignancies. Therefore, we aimed to develop a predictive model to help medical staff promptly screen patients at a high risk of perianal infection during chemotherapy. Design This was a single-centre prospective observational study. Setting This study was conducted in a tertiary teaching hospital in Chengdu, China. Participants The study sample comprised 850 patients with haematological malignancies who underwent chemotherapy at the department of haematology or our hospital between January 2021 and June 2022. Interventions The included patients were randomly divided into training and validation groups in a 7:3 ratio. Based on the discharge diagnosis, patients with perianal infection were selected as the case group and the other patients were selected as the control group. Outcome measure The main outcome measure was the occurrence of perianal infections. Results A predictive model for perianal infections was established. A history of perianal infection, haemorrhoids, constipation and duration of diarrhoea were independent risk factors. The area under the curve of the The area under the receiver operating characteristic (ROC) curve for the training and validation groups were 0.784 (95% CI 0.727 to 0.841) and 0.789 (95% CI 0.818 to 0.885), respectively. Additionally, the model had good calibration in both the training and validation groups with a non-significant Hosmer-Lemeshow test (p=0.999 and 0.482, respectively). Conclusions The risk prediction model, including a history of perianal infection, history of haemorrhoids, constipation and duration of diarrhoea ≥3 days of perianal infection in patients with haematological malignancies during chemotherapy, has good prediction reliability and can be helpful in guiding clinical medical staff in screening and early intervention of high-risk groups. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1136/bmjopen-2023-074196 |
| الإتاحة: |
https://doi.org/10.1136/bmjopen-2023-074196Test |
| حقوق: |
http://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: |
edsbas.67141221 |
| قاعدة البيانات: |
BASE |
