دورية أكاديمية
A mathematical model of healthy and dystrophic skeletal muscle biomechanics
| العنوان: | A mathematical model of healthy and dystrophic skeletal muscle biomechanics |
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| المؤلفون: | M. Stefanati, C. Villa, Y. Torrente, J. F. Rodriguez Matas |
| المساهمون: | M. Stefanati, C. Villa, Y. Torrente, J.F. Rodriguez Matas |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2020 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Skeletal muscle model, Skeletal fiber model, Skeletal mathematical model, Muscle mathematical model, Diaphragm mathematical model, C57B1 And mdx diaphragm mathematical model, Mouse diaphragm mathematical model, Settore MED/26 - Neurologia |
| الوصف: | Duchenne Muscular Dystrophy (DMD) is a common X-linked disease, caused by mutations in the gene encoding dystrophin and characterized by widespread muscle damage that invariably leads to paralysis and death. Lack of dystrophin in the muscles of DMD patients determines an increased fragility of muscle fibers, leading to repeated cycles of necrosis and regeneration that result in failed regeneration, increased fibrosis and progressive loss of muscle function. In this work, we propose a three-dimensional chemo-mechanical mathematical model of skeletal muscle in DMD. This model is based on stress-strain mechanical data of the muscle and studies of changes in fiber structure and interaction aiming to shade light into the biophysical mechanisms regulating muscle contraction. The results show that the model is able to reproduce the experimental data of maximum isometric force, maximum contraction velocity and concentric normalized F-V curve for the healthy and dystrophic muscle. Furthermore, the model is capable of predicting the force-velocity response of the muscle to eccentric loading without explicitly imposing its functional form in the formu- lation, and it is able to reproduce the concentric normalized F-V curve of the healthy fiber, as an additional proof of the predictive capabilities of the model. The resulting model rep- resents a novel approach to study DMD pathogenesis by providing insights into the un- derlying mechanisms of muscle response to force associated with the impaired muscle functionality. Moreover, it could be an innovative tool for researchers to predict muscle response under conditions that are not possible to explore in the laboratory and an im- portant step towards a new paradigm of in-silico trials that could allow identifying novel therapies bypassing the use of animal models. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000502888000005; volume:134; numberofpages:16; journal:JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS; http://hdl.handle.net/2434/711953Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85072902844 |
| DOI: | 10.1016/j.jmps.2019.103747 |
| الإتاحة: | https://doi.org/10.1016/j.jmps.2019.103747Test http://hdl.handle.net/2434/711953Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.66C44561 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jmps.2019.103747 |
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