التفاصيل البيبلوغرافية
| العنوان: |
Clinical outcomes and predictors of bleomycin polidocanol foam sclerotherapy treatment response in venous malformations |
| المؤلفون: |
Ni, Bin, Liu, Jing-wen, Fan, Xue-qiang, He, Bin, Nie, Qiang-qiang, Ye, Zhi-dong, Liu, Peng, Wen, Jian-yan |
| المساهمون: |
Major New Drug Creation Special Project, National Natural Science Foundation of China, the International S&T cooperation program, National High Level Hospital Clinical Research Funding |
| المصدر: |
Journal of International Medical Research ; volume 52, issue 1 ; ISSN 0300-0605 1473-2300 |
| بيانات النشر: |
SAGE Publications |
| سنة النشر: |
2024 |
| مصطلحات موضوعية: |
Biochemistry (medical), Cell Biology, Biochemistry, General Medicine |
| الوصف: |
Objective To evaluate the safety and efficacy of bleomycin polidocanol foam (BPF) sclerotherapy for venous malformations (VMs) and analyze the associated clinical outcomes and predictors. Methods We retrospectively assessed BPF sclerotherapy outcomes in 138 patients with VMs. We analyzed pain levels, lesion volume reduction, and subjective perception of response. Logistic regression analysis was performed to identify potential predictors of treatment outcome. Additionally, we carefully monitored and recorded complications. Results There was a notable average reduction in lesion volume by 78.50% ± 15.71%. The pain numerical rating scale (NRS) score decreased from 4.17 ± 2.63 prior to treatment to 1.05 ± 1.54 afterward, and 70.3% of the patients experienced effective relief after a single BPF treatment. Multivariate analysis revealed that a high baseline NRS (odds ratio [OR]: 4.026) and elevated activated partial thromboplastin time (APTT, OR: 1.200) were positive predictors of pain reduction. Additionally, a high baseline NRS score (OR: 1.992) and elevated thrombocytocrit (PCT, OR: 2.543) were positive predictors of incomplete postoperative pain relief. Minor complications occurred in 31 (22.46%) patients. Conclusion BPF sclerotherapy is safe and effective for VMs, resulting in significant reduction in lesion volume, improved symptoms, and minimal complications. APTT and PCT levels are important predictors of pain outcomes following BPF treatment. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1177/03000605231223441 |
| الإتاحة: |
https://doi.org/10.1177/03000605231223441Test |
| حقوق: |
https://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: |
edsbas.667F8135 |
| قاعدة البيانات: |
BASE |
