Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis.

التفاصيل البيبلوغرافية
العنوان:	Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis.
المؤلفون:	E. A. Stahl, D. Wegmann, G. Trynka, J. Gutierrez Achury, R. Do, B. F. Voight, P. Kraft, R. Chen, H. J. Kallberg, F. A. S, D. G. Replication, M. a. Consortium, M. I. Genetics, S. Kathiresan, C. Wijmenga, P. K. Gregersen, L. Alfredsson, K. A. Siminovitch, J. Worthington, P. I. W, S. Raychaudhuri, R. M. Plenge, Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, McCulloch LJ, Ferreira T, Grallert H, Amin N, Wu G, Willer CJ, Raychaudhuri S, McCarroll SA, Langenberg C, Hofmann OM, Dupuis J, Qi L, Segrè AV, van Hoek M, Navarro P, Ardlie K, Balkau B, Benediktsson R, Bennett AJ, Blagieva R, Boerwinkle E, Bonnycastle LL, Boström KB, Bravenboer B, Bumpstead S, Burtt NP, Charpentier G, Chines PS, Cornelis M, Couper DJ, Crawford G, Doney AS, Elliott KS, Elliott AL, Erdos MR, Fox CS, Franklin CS, Ganser M, Gieger C, Grarup N, Green T, Griffin S, Groves CJ, Guiducci C, Hadjadj S, Hassanali N, Herder C, Isomaa B, Jackson AU, Johnson PR, Jørgensen T, Kao WH, Klopp N, Kong A, Kraft P, Kuusisto J, Lauritzen T, Li M, Lieverse A, Lindgren CM, Lyssenko V, Marre M, Meitinger T, Midthjell K, Morken MA, Narisu N, Nilsson P, Owen KR, Payne F, Perry JR, Petersen AK, Platou C, Proença C, Prokopenko I, Rathmann W, Rayner NW, Robertson NR, Rocheleau G, Roden M, Sampson MJ, Saxena R, Shields BM, Shrader P, Sigurdsson G, Sparsø T, Strassburger K, Stringham HM, Sun Q, Swift AJ, Thorand B, Tichet J, Tuomi T, van Dam RM, van Haeften TW, van Herpt T, van Vliet Ostaptchouk JV, Walters GB, Weedon MN, Wijmenga C, Witteman J, Bergman RN, Cauchi S, Collins FS, Gloyn AL, Gyllensten U, Hansen T, Hide WA, Hitman GA, Hofman A, Hunter DJ, Hveem K, Laakso M, Mohlke KL, Morris AD, Palmer CN, Pramstaller PP, Rudan I, Sijbrands E, Stein LD, Tuomilehto J, Uitterlinden A, Walker M, Wareham NJ, Watanabe RM, Abecasis GR, Boehm BO, Campbell H, Daly MJ, Hattersley AT, Hu FB, Meigs JB, Pankow JS, Pedersen O, Wichmann HE, Barroso I, Florez JC, Frayling TM, Groop L, Sladek R, Thorsteinsdottir U, Wilson JF, Illig T, Froguel P, van Duijn CM, Stefansson K, Altshuler D, Boehnke M, McCarthy MI, Kathiresan S, Williams G, Nathan DM, MacRae CA, O'Donnell CJ, Ardissino D, Merlini PA, Berzuini C, Bernardinelli L, Peyvandi F, Tubaro M, Celli P, Ferrario M, Fetiveau R, Marziliano N, Casari G, Galli M, Rossi M, Bernardi F, Zonzin P, Piazza A, Mannucci PM, Schwartz SM, Siscovick DS, Yee J, Friedlander Y, Elosua R, Marrugat J, Lucas G, Subirana I, Sala J, Ramos R, Salomaa V, Havulinna AS, Peltonen L, Melander O, Berglund G, Hirschhorn JN, Asselta R, Duga S, Spreafico M, Musunuru K, Purcell S, Surti A, Gianniny L, Mirel D, Parkin M, Burtt N, Gabriel SB, RIBICHINI, Flavio Luciano
المساهمون:	E. A., Stahl, D., Wegmann, G., Trynka, J., Gutierrez Achury, R., Do, B. F., Voight, P., Kraft, R., Chen, H. J., Kallberg, F. A., S., D. G., Replication, M. a., Consortium, M. I., Genetic, S., Kathiresan, C., Wijmenga, P. K., Gregersen, L., Alfredsson, K. A., Siminovitch, J., Worthington, P. I., W., S., Raychaudhuri, R. M., Plenge, Voight, Bf, Scott, Lj, Steinthorsdottir, V, Morris, Ap, Dina, C, Welch, Rp, Zeggini, E, Huth, C, Aulchenko, Y, Thorleifsson, G, Mcculloch, Lj, Ferreira, T, Grallert, H, Amin, N, Wu, G, Willer, Cj, Raychaudhuri, S, Mccarroll, Sa, Langenberg, C, Hofmann, Om, Dupuis, J, Qi, L, Segrè, Av, van Hoek, M, Navarro, P, Ardlie, K, Balkau, B, Benediktsson, R, Bennett, Aj, Blagieva, R, Boerwinkle, E, Bonnycastle, Ll, Boström, Kb, Bravenboer, B, Bumpstead, S, Burtt, Np, Charpentier, G, Chines, P, Cornelis, M, Couper, Dj, Crawford, G, Doney, A, Elliott, K, Elliott, Al, Erdos, Mr, Fox, C, Franklin, C, Ganser, M, Gieger, C, Grarup, N, Green, T, Griffin, S, Groves, Cj, Guiducci, C, Hadjadj, S, Hassanali, N, Herder, C, Isomaa, B, Jackson, Au, Johnson, Pr, Jørgensen, T, Kao, Wh, Klopp, N, Kong, A, Kraft, P, Kuusisto, J, Lauritzen, T, Li, M, Lieverse, A, Lindgren, Cm, Lyssenko, V, Marre, M, Meitinger, T, Midthjell, K, Morken, Ma, Narisu, N, Nilsson, P, Owen, Kr
سنة النشر:	2012
المجموعة:	Università degli Studi di Verona: Catalogo dei Prodotti della Ricerca (IRIS)
مصطلحات موضوعية:	Arthriti, Rheumatoid, genetics, Bayes Theorem, Cardiovascular Disease, Case-Control Studies, Celiac Disease, Diabetes Mellitu, Type 2, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Multifactorial Inheritance, Polymorphism, Single Nucleotide
الوصف:	The genetic architectures of common, complex diseases are largely uncharacterized. We modeled the genetic architecture underlying genome-wide association study (GWAS) data for rheumatoid arthritis and developed a new method using polygenic risk-score analyses to infer the total liability-scale variance explained by associated GWAS SNPs. Using this method, we estimated that, together, thousands of SNPs from rheumatoid arthritis GWAS explain an additional 20\% of disease risk (excluding known associated loci). We further tested this method on datasets for three additional diseases and obtained comparable estimates for celiac disease (43\% excluding the major histocompatibility complex), myocardial infarction and coronary artery disease (48\%) and type 2 diabetes (49\%). Our results are consistent with simulated genetic models in which hundreds of associated loci harbor common causal variants and a smaller number of loci harbor multiple rare causal variants. These analyses suggest that GWAS will continue to be highly productive for the discovery of additional susceptibility loci for common diseases.
نوع الوثيقة:	article in journal/newspaper
اللغة:	English
العلاقة:	info:eu-repo/semantics/altIdentifier/pmid/22446960; info:eu-repo/semantics/altIdentifier/wos/WOS:000303416300006; volume:44; firstpage:483; lastpage:489; numberofpages:6; journal:NATURE GENETICS; http://hdl.handle.net/11562/475153Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84860333083; http://dx.doi.org/10.1038/ng.2232Test
DOI:	10.1038/ng.2232
الإتاحة:	https://doi.org/10.1038/ng.2232Test http://hdl.handle.net/11562/475153Test
رقم الانضمام:	edsbas.666E7E26
قاعدة البيانات:	BASE

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الوصف
DOI:	10.1038/ng.2232