التفاصيل البيبلوغرافية
| العنوان: |
Microsatellite instability-high is rare events in refractory pediatric solid tumors |
| المؤلفون: |
Taro Yoshida (11885855), Hideki Muramatsu (840463), Manabu Wakamatsu (11885858), Rieko Taniguchi (11885861), Daisuke Ichikawa (2430652), Masato Nakaguro (11885864), Atsushi Natsume (211021), Yoshiyuki Takahashi (41489) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Medicine, Biotechnology, Sociology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Microsatellite instability, mismatch repair gene, pediatric solid tumor |
| الوصف: |
Microsatellite instability (MSI)-high status is associated with good responsiveness to immune checkpoint inhibitors. Although MSI-high status has been actively investigated in pediatric brain tumors, studies of other pediatric solid tumors are lacking. Among 334 consecutive pediatric patients with solid tumors, we retrospectively analyzed formalin-fixed paraffin-embedded tumor tissues of 36 of 74 patients (49%) who died of disease. We assessed the MSI status in these tissues using five multiplexed markers. The results revealed that none of the patients had an MSI-high status. These results indicate that MSI-high status is a rare event in pediatric patients with refractory/relapsed solid tumors. Supplemental data for this article is available online at https://doi.org/10.1080/08880018.2021.1998266Test |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Microsatellite_instability-high_is_rare_events_in_refractory_pediatric_solid_tumors/17702837Test |
| DOI: |
10.6084/m9.figshare.17702837.v1 |
| الإتاحة: |
https://doi.org/10.6084/m9.figshare.17702837.v1Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.65E1D323 |
| قاعدة البيانات: |
BASE |
