دورية أكاديمية
HMGB1 induces neutrophil dysfunction in experimental sepsis and in patients who survive septic shock
| العنوان: | HMGB1 induces neutrophil dysfunction in experimental sepsis and in patients who survive septic shock |
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| المؤلفون: | Grégoire, Murielle, Tadié, Jean-Marc, Uhel, Fabrice, Gacouin, Arnaud, Piau, Caroline, Bone, Nathaniel, Le Tulzo, Yves, Abraham, Edward, Tarte, Karin, Zmijewski, Jaroslaw W. |
| المساهمون: | Etablissement français du sang Rennes (EFS Bretagne), Service d’immunologie, de thérapie cellulaire et d’hématopoïèse, Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou, Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre d'Investigation Clinique Rennes (CIC), Université de Rennes (UR)-Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou -Institut National de la Santé et de la Recherche Médicale (INSERM), Service des maladies infectieuses et réanimation médicale Rennes = Infectious Disease and Intensive Care Rennes, University of Alabama at Birmingham Birmingham (UAB), Wake Forest University, Comite de la Recherche Clinique et Translationnelle (CORECT), CHU Rennes, France, Association pour la Recherche contre le Cancer (ARC), U.S. National Institutes of Health, Heart, Lung, and Blood Institute HL107585 |
| المصدر: | ISSN: 0741-5400 ; Journal of Leukocyte Biology ; https://univ-rennes.hal.science/hal-01533343Test ; Journal of Leukocyte Biology, 2017, 101 (6), pp.1281-1287. ⟨10.1189/jlb.5HI0316-128RR⟩. |
| بيانات النشر: | HAL CCSD Society for Leukocyte Biology |
| سنة النشر: | 2017 |
| المجموعة: | Université de Rennes 1: Publications scientifiques (HAL) |
| مصطلحات موضوعية: | nadph oxidase, sepsis, hmgb1, neutrophils, immunosuppression, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.IMM]Life Sciences [q-bio]/Immunology |
| الوصف: | International audience ; Sepsis is accompanied by the initial activation of proinflammatory pathways and long-lasting immunosuppression that appears to contribute to late-occurring mortality. Although high-mobility group box 1 (HMGB1) is involved in many aspects of inflammation, its role in sepsis-induced immune suppression remains unclear. In this study, we examined HMGB1's contribution to neutrophil NADPH oxidase activity dysfunction and associated neutrophil-dependent bacterial clearance in mice subjected to sepsis and in patients who survive septic shock. Using a murine model of polymicrobial septic peritonitis, we demonstrated that treatment with anti-HMGB1 Ab significantly diminished sepsis-induced dysfunction of neutrophil NADPH oxidase activity. In a subsequent set of experiments, we found that blocking HMGB1 preserved the ability of neutrophils from patients recovering from septic shock to activate NADPH oxidase. Taken together, our data suggest that HMGB1 accumulation in the late phase of sepsis plays a specific role in the development of postsepsis immunosuppression and specifically affects neutrophil-dependent antibacterial defense mechanisms. Thus, blocking HMGB1 may be a promising therapeutic intervention to diminish the adverse effects of sepsis-induced immunosuppression. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/27965385; hal-01533343; https://univ-rennes.hal.science/hal-01533343Test; https://univ-rennes.hal.science/hal-01533343/documentTest; https://univ-rennes.hal.science/hal-01533343/file/HMGB1%20induces%20neutrophil%20dysfunction_accepted.pdfTest; PUBMED: 27965385 |
| DOI: | 10.1189/jlb.5HI0316-128RR |
| الإتاحة: | https://doi.org/10.1189/jlb.5HI0316-128RRTest https://univ-rennes.hal.science/hal-01533343Test https://univ-rennes.hal.science/hal-01533343/documentTest https://univ-rennes.hal.science/hal-01533343/file/HMGB1%20induces%20neutrophil%20dysfunction_accepted.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.65CB96D9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1189/jlb.5HI0316-128RR |
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