التفاصيل البيبلوغرافية
| العنوان: |
Monocytic Myeloid Derived Suppressor Cells in Hematological Malignancies |
| المؤلفون: |
Giuseppe Alberto Palumbo, Nunziatina Laura Parrinello, Cesarina Giallongo, Emanuele D’Amico, Aurora Zanghì, Fabrizio Puglisi, Concetta Conticello, Annalisa Chiarenza, Daniele Tibullo, Francesco Di Raimondo, Alessandra Romano |
| المصدر: |
International Journal of Molecular Sciences; Volume 20; Issue 21; Pages: 5459 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2019 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
microenvironment, multiple myeloma, chronic lymphatic leukemia, chronic myeloid leukemia, lymphoma MDSC |
| جغرافية الموضوع: |
agris |
| الوصف: |
In the era of novel agents and immunotherapies in solid and liquid tumors, there is an emerging need to understand the cross-talk between the neoplastic cells, the host immune system, and the microenvironment to mitigate proliferation, survival, migration and resistance to drugs. In the microenvironment of hematological tumors there are cells belonging to the normal bone marrow, extracellular matrix proteins, adhesion molecules, cytokines, and growth factors produced by both stromal cells and neoplastic cells themselves. In this context, myeloid suppressor cells are an emerging sub-population of regulatory myeloid cells at different stages of differentiation involved in cancer progression and chronic inflammation. In this review, monocytic myeloid derived suppressor cells and their potential clinical implications are discussed to give a comprehensive vision of their contribution to lymphoproliferative and myeloid disorders. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Biochemistry; https://dx.doi.org/10.3390/ijms20215459Test |
| DOI: |
10.3390/ijms20215459 |
| الإتاحة: |
https://doi.org/10.3390/ijms20215459Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.65BE92C2 |
| قاعدة البيانات: |
BASE |
