دورية أكاديمية
أعرض في EDS

Coinfections and differential diagnosis in immunocompetent patients with uveitis of infectious origin

التفاصيل البيبلوغرافية
العنوان: Coinfections and differential diagnosis in immunocompetent patients with uveitis of infectious origin
المؤلفون: Alejandra de-la-Torre, Juanita Valdés-Camacho, Clara López de Mesa, Andrés Uauy-Nazal, Juan David Zuluaga, Lina María Ramírez-Páez, Felipe Durán, Elizabeth Torres-Morales, Jessica Triviño, Mateo Murillo, Alba Cristina Peñaranda, Juan Carlos Sepúlveda-Arias, Jorge Enrique Gómez-Marín
المصدر: BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-10 (2019)
بيانات النشر: BMC
سنة النشر: 2019
المجموعة: Directory of Open Access Journals: DOAJ Articles
مصطلحات موضوعية: Diagnosis, Co-infections, Immunocompetent, Goldmann-Witmer, PCR, Ocular toxoplasmosis, Infectious and parasitic diseases, RC109-216
الوصف: Background Making a definite diagnosis of infectious uveitis is a challenging task because many other infectious, and non-infectious uveitis, may have similar non-specific symptoms and overlapping clinical appearances. Co-infections in immunocompetent patients are not frequently proved with traditional serologic-diagnostic tools. Methods Descriptive transversal study, in a Uveitis Service of an Ophthalmology Reference Center, in Bogotá, Colombia, from July 2014 to February 2016. Aqueous humor (AH) and/or vitreous fluid, blood and serum samples were collected from consecutive patients suspected of having infectious uveitis. The diagnosis of ocular toxoplasmosis (OT) was confirmed by the Goldmann–Witmer coefficient (GWC) and by polymerase chain reaction (PCR). Differential diagnosis by PCR in AH was done for viral origin such as Cytomegalovirus (CMV), Herpes simplex virus type 1 (HSV1), Herpes simplex virus type 2 (HSV2), Varicella zoster virus (VZV), Epstein-Barr virus (EBV) and Mycobacterium tuberculosis. Results In 66 Colombian patients with uveitis of presumed infectious origin: 22 (33.3%) were confirmed as OT, 16 (24.2%) as undetermined OT, five (7.5%) as co-infections and 23 (34.8%) as other uveitis. Toxoplasma coinfection with M. tuberculosis was identified in one case by PCR and in four cases with HSV by GWC. The initial clinical diagnosis changed, after laboratory examination, in 21 cases (31.8%). Conclusions Clinical diagnosis can be changed by laboratory examination in a significant proportion of cases of uveitis. Diagnosis of OT should combine the use of PCR and GWC to reach the maximum of confirmation of cases. The use of multiple laboratory methods is necessary to identify co-infections and viral infections that can mimic OT in immunocompetent patients.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 1471-2334
العلاقة: http://link.springer.com/article/10.1186/s12879-018-3613-8Test; https://doaj.org/toc/1471-2334Test; https://doaj.org/article/0bde1d6bed7b4b1e90351d5379088073Test
DOI: 10.1186/s12879-018-3613-8
الإتاحة: https://doi.org/10.1186/s12879-018-3613-8Test
https://doaj.org/article/0bde1d6bed7b4b1e90351d5379088073Test
رقم الانضمام: edsbas.659590B7
قاعدة البيانات: BASE
الوصف
تدمد:14712334
DOI:10.1186/s12879-018-3613-8