دورية أكاديمية

The Role of Catecholamines in Pathophysiological Liver Processes

التفاصيل البيبلوغرافية
العنوان: The Role of Catecholamines in Pathophysiological Liver Processes
المؤلفون: Lelou, Elise, Corlu, Anne, Nesseler, Nicolas, Rauch, Claudine, Mallédant, Yannick, Seguin, Philippe, Aninat, Caroline
المساهمون: Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou, This work was supported by the Centre National de la Recherche Scientifique, the Institut National de la Santé et de la Recherche Médicale (INSERM), the University of Rennes, and the Ligue contre le cancer (Comité 22-41-44).
المصدر: ISSN: 2073-4409 ; Cells ; https://hal.science/hal-03632170Test ; Cells, 2022, 11 (6), pp.1021. ⟨10.3390/cells11061021⟩.
بيانات النشر: HAL CCSD
MDPI
سنة النشر: 2022
المجموعة: Université de Rennes 1: Publications scientifiques (HAL)
مصطلحات موضوعية: dopamine, epinephrine, hepatic cells, norepinephrine, sympathetic innervation, [SDV]Life Sciences [q-bio]
الوصف: International audience ; Over the last few years, the number of research publications about the role of catecholamines (epinephrine, norepinephrine, and dopamine) in the development of liver diseases such as liver fibrosis, fatty liver diseases, or liver cancers is constantly increasing. However, the mechanisms involved in these effects are not well understood. In this review, we first recapitulate the way the liver is in contact with catecholamines and consider liver implications in their metabolism. A focus on the expression of the adrenergic and dopaminergic receptors by the liver cells is also discussed. Involvement of catecholamines in physiological (glucose metabolism, lipids metabolism, and liver regeneration) and pathophysiological (impact on drug-metabolizing enzymes expression, liver dysfunction during sepsis, fibrosis development, or liver fatty diseases and liver cancers) processes are then discussed. This review highlights the importance of understanding the mechanisms through which catecholamines influence liver functions in order to draw benefit from the adrenergic and dopaminergic antagonists currently marketed. Indeed, as these molecules are well-known drugs, their use as therapies or adjuvant treatments in several liver diseases could be facilitated.
نوع الوثيقة: article in journal/newspaper
اللغة: English
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35326472; hal-03632170; https://hal.science/hal-03632170Test; https://hal.science/hal-03632170/documentTest; https://hal.science/hal-03632170/file/cells-11-01021-v2.pdfTest; PUBMED: 35326472; PUBMEDCENTRAL: PMC8947265; WOS: 000775658300001
DOI: 10.3390/cells11061021
الإتاحة: https://doi.org/10.3390/cells11061021Test
https://hal.science/hal-03632170Test
https://hal.science/hal-03632170/documentTest
https://hal.science/hal-03632170/file/cells-11-01021-v2.pdfTest
حقوق: http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess
رقم الانضمام: edsbas.64DD28CE
قاعدة البيانات: BASE