دورية أكاديمية
Efficacy and toxicity of adjuvant radiotherapy in recurrent melanoma after adjuvant immunotherapy
| العنوان: | Efficacy and toxicity of adjuvant radiotherapy in recurrent melanoma after adjuvant immunotherapy |
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| المؤلفون: | Bhave, Prachi, Hong, Angela, Lo, Serigne N, Johnson, Rebecca, Mangana, Johanna, Johnson, Douglas B, Dulgar, Ozgecan, Eroglu, Zeynep, Yeoh, Hui-Ling, Haydon, Andrew, Lodde, Georg C, Livingstone, Elisabeth, Khattak, Adnan, Kähler, Katharina, Hausschild, Axel, McArthur, Grant A, Menzies, Alexander Maxwell, Long, Georgina, Wang, Wei, Carlino, Matteo S |
| المصدر: | Bhave, Prachi; Hong, Angela; Lo, Serigne N; Johnson, Rebecca; Mangana, Johanna; Johnson, Douglas B; Dulgar, Ozgecan; Eroglu, Zeynep; Yeoh, Hui-Ling; Haydon, Andrew; Lodde, Georg C; Livingstone, Elisabeth; Khattak, Adnan; Kähler, Katharina; Hausschild, Axel; McArthur, Grant A; Menzies, Alexander Maxwell; Long, Georgina; Wang, Wei; Carlino, Matteo S (2023). Efficacy and toxicity of adjuvant radiotherapy in recurrent melanoma after adjuvant immunotherapy. Journal for ImmunoTherapy of Cancer, 11(3):e006629. |
| بيانات النشر: | BMJ Publishing Group |
| سنة النشر: | 2023 |
| المجموعة: | University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| مصطلحات موضوعية: | Dermatology Clinic, 610 Medicine & health, Cancer Research, Pharmacology, Oncology, Molecular Medicine, Immunology, Immunology and Allergy, adjuvants, immunologic, immune checkpoint inhibitors, immunotherapy, melanoma, radiotherapy |
| الوصف: | BackgroundIn patients with stage III melanoma, despite surgical resection and adjuvant systemic therapy, locoregional recurrences still occur. The randomized, phase III Trans-Tasman Radiation Oncology Group (TROG) 02.01 trial demonstrated that adjuvant radiotherapy (RT) after complete lymphadenectomy (CLND) halves the incidence of melanoma recurrence within local nodal basins without improving overall survival or quality of life. However, the study was conducted prior to the current era of adjuvant systemic therapies and when CLND was the standard approach for microscopic nodal disease. As such, there is currently no data on the role of adjuvant RT in patients with melanoma who recur during or after adjuvant immunotherapy, including those that may or may not have undergone prior CLND. In this study, we aimed to answer this question.MethodsPatients with resected stage III melanoma who received adjuvant anti-programmed cell death protein-1 (PD-1) (±ipilimumab) immunotherapy with a subsequent locoregional (lymph node and/or in-transit metastases) recurrence were retrospectively identified. Multivariable logistic and Cox regression analyses were conducted. Primary outcome was rate of subsequent locoregional recurrence; secondary outcomes were locoregional recurrence-free survival (lr-RFS2) and overall RFS (RFS2) to second recurrence.ResultsIn total, 71 patients were identified: 42 (59%) men, 30 (42%) BRAF V600E mutant, 43 (61%) stage IIIC at diagnosis. Median time to first recurrence was 7 months (1–44), 24 (34%) received adjuvant RT and 47 (66%) did not. Thirty-three patients (46%) developed a second recurrence at a median of 5 months (1–22). The rate of locoregional relapse at second recurrence was lower in those who received adjuvant RT (8%, 2/24) compared with those who did not (36%, 17/47, p=0.01). Adjuvant RT at first recurrence was associated with an improved lr-RFS2 (HR 0.16, p=0.015), with a trend towards an improved RFS2 (HR 0.54, p=0.072) and no effect on risk of distant recurrence or overall ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2051-1426 |
| العلاقة: | https://www.zora.uzh.ch/id/eprint/239286/1/ZORA_e006629_full.pdfTest; info:pmid/36889810; urn:issn:2051-1426 |
| DOI: | 10.5167/uzh-239286 |
| DOI: | 10.1136/jitc-2022-006629 |
| الإتاحة: | https://doi.org/10.5167/uzh-23928610.1136/jitc-2022-006629Test https://www.zora.uzh.ch/id/eprint/239286Test/ https://www.zora.uzh.ch/id/eprint/239286/1/ZORA_e006629_full.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess ; Creative Commons: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) ; http://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: | edsbas.64DB08B3 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20511426 |
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| DOI: | 10.5167/uzh-239286 |