رسالة جامعية
Avaliação dos efeitos da privação alimentar sobre o condicionamento ambiental induzido por diferentes drogas de abuso ; Evaluation of the effects of food deprivation on the environmental conditioning induced by different drugs of abuse
| العنوان: | Avaliação dos efeitos da privação alimentar sobre o condicionamento ambiental induzido por diferentes drogas de abuso ; Evaluation of the effects of food deprivation on the environmental conditioning induced by different drugs of abuse |
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| المؤلفون: | Hollais, Andre Willian UNIFESP |
| المساهمون: | Longo, Beatriz Monteiro UNIFESP, Universidade Federal de São Paulo (UNIFESP), http://lattes.cnpq.br/0068789063590867Test, http://lattes.cnpq.br/0245964878412260Test, Marinho, Eduardo Ary Villela UNIFESP, http://lattes.cnpq.br/4549243422662681Test |
| بيانات النشر: | Universidade Federal de São Paulo (UNIFESP) |
| سنة النشر: | 2017 |
| المجموعة: | Universidade Federal de São Paulo (UNIFESP): Repositório Institucional |
| مصطلحات موضوعية: | Food deprivation, Conditioned place preference, Ethanol, Nicotine, Morphine, Femproporex, C-Fos, Orexin, Saúde mental, Reforma psiquiátrica, Análise institucional, Oferta e demanda, Analisadores |
| جغرافية الموضوع: | São Paulo |
| الوصف: | Cumulative experimental evidence points to the existence of positive correlation between the exposure to different stressors and increased vulnerability to addiction. There is a need to search for stress markers which more reliably reflect the human condition, in laboratory animal models. Among them food deprivation has been considered. Indeed, it has been demonstrated that food deprivation, followed by exposure to different drugs of abuse is able to enhance and/or facilitate drug dependence in animal models, including the conditioning place preference (CPP) paradigm.In this scenario, the aim of the present study was to investigate the tardive effects of diurnal food deprivation on CPP induced by different drugs with potential for abuse, the front mechanistic approaches, pharmacological and immunohistochemistry. For Swiss mice adult males were deprived of daytime power for 4 days. After 21 days of the end of food deprivation, the animals were conditioned to ethanol, morphine, nicotine or femproporex and submitted to the postconditioning test to evaluate the CPP. Our results indicate that daytime food deprivation was able to induce a greater resistance to extinction CPP ethanol, and potentiate the expression of nicotine-induced CPP and fenproporex. However, seems not to have altered sensitivity to morphine conditioning. The immunohistochemical point of view, the daytime food deprivation protocol was able to induce greater immunoreactivity to c-fos protein in the nucleus accumbens, basolateral amygdala, lateral hypothalamus and ventral tegmental area, immediately after the food deprivation in However, this increased expression was not observed 7, 14 and 21 days after the end of food deprivation. However, the pharmacologically treatment with SB-334867, applied simultaneously to food deprivation regimen was able to prevent the facilitating effects of starvation on the conditioned place preference induced fenproporex. Taken together, our results suggest that daytime food deprivation was able to increase vulnerability ... |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| وصف الملف: | 276 f.; application/pdf |
| اللغة: | Portuguese |
| العلاقة: | https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=5557652Test; http://repositorio.unifesp.br/handle/11600/50076Test |
| الإتاحة: | http://repositorio.unifesp.br/handle/11600/50076Test https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=5557652Test |
| حقوق: | Acesso aberto |
| رقم الانضمام: | edsbas.6372703F |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |